An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737. - Wikidata - awgldk - TriplyDB

An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737.

An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737.

http://www.wikidata.org/entity/Q35266213

about

Mitochondrial apoptosis and BH3 mimetics Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo Detailed Functional and Proteomic Characterization of Fludarabine Resistance in Mantle Cell Lymphoma Cells Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies.Targeting mTORC1-mediated metabolic addiction overcomes fludarabine resistance in malignant B cells.Identification of Small Inhibitory Molecules Targeting the Bfl-1 Anti-Apoptotic Protein That Alleviates Resistance to ABT-737.Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer.Acidosis Sensing Receptor GPR65 Correlates with Anti-Apoptotic Bcl-2 Family Member Expression in CLL Cells: Potential Implications for the CLL Microenvironment Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications.New agents for the treatment of lymphoid leukemia and lymphoma: focus on recent FDA approvals.Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer.Resistance to ABT-737 in activated T lymphocytes: molecular mechanisms and reversibility by inhibition of the calcineurin-NFAT pathway.Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics miR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies.A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199)Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer.Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer.An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1.BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells.Vinblastine rapidly induces NOXA and acutely sensitizes primary chronic lymphocytic leukemia cells to ABT-737.Toward a cure for chronic lymphocytic leukemia: an attack on multiple fronts MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation Development of venetoclax for therapy of lymphoid malignancies.Targeting the B-cell lymphoma/leukemia 2 family in cancer.Biomarkers of therapeutic response to BCL2 antagonists in cancer.CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia.Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.Lipidoid nanoparticle mediated silencing of Mcl-1 induces apoptosis in mantle cell lymphoma.Bcl-2 phosphorylation confers resistance on chronic lymphocytic leukaemia cells to the BH3 mimetics ABT-737, ABT-263 and ABT-199 by impeding direct binding.The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1.BCL-2 family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignancies.Gene expression profiling of tumor-initiating stem cells from mouse Krebs-2 carcinoma using a novel marker of poorly differentiated cells Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199).Microarray determination of Bcl-2 family protein inhibition sensitivity in breast cancer cells.The BH3-only protein Puma plays an essential role in p53-mediated apoptosis of chronic lymphocytic leukemia cells.

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An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737.

http://www.wikidata.org/entity/Q35266213

description

2011 nî lūn-bûn

@nan

2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

An antiapoptotic BCL-2 family ...... mphocytic leukemia to ABT-737.

@ast

An antiapoptotic BCL-2 family ...... mphocytic leukemia to ABT-737.

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type

label

An antiapoptotic BCL-2 family ...... mphocytic leukemia to ABT-737.

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An antiapoptotic BCL-2 family ...... mphocytic leukemia to ABT-737.

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prefLabel

An antiapoptotic BCL-2 family ...... mphocytic leukemia to ABT-737.

@ast

An antiapoptotic BCL-2 family ...... mphocytic leukemia to ABT-737.

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An antiapoptotic BCL-2 family ...... ymphocytic leukemia to ABT-737

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Brian T Hill

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Janet A Houghton

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Jaroslaw P Maciejewski

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Jennifer Devecchio

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Kamini Singh

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Lisa A Rybicki

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Matt Kalaycio

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Sayer Al-Harbi

http://www.w3.org/2001/XMLSchema#string

Suparna Mazumder

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P2860

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

miR-15 and miR-16 induce apoptosis by targeting BCL2

The Bcl-2 apoptotic switch in cancer development and therapy

Genomic aberrations and survival in chronic lymphocytic leukemia

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

ONCOMINE: a cancer microarray database and integrated data-mining platform

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia

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3579-3590

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10.1182/BLOOD-2011-03-340364

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13

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Gaurav Choudhary

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