Fatty acid metabolism and insulin secretion in pancreatic beta cells.
about
A non-traditional model of the metabolic syndrome: the adaptive significance of insulin resistance in fasting-adapted sealsOverexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cellsDeletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cellsTissue-dependent loss of phosphofructokinase-M in mice with interrupted activity of the distal promoter: impairment in insulin secretionFeasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cellGlucose metabolism, islet architecture, and genetic homogeneity in imprinting of [Ca2+](i) and insulin rhythms in mouse islets.Analysis of gene expression in pancreatic islets from diet-induced obese mice.Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms.Adipose differentiation-related protein regulates lipids and insulin in pancreatic isletsReactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerolPalmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets.Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency.Perilipin 5 regulates islet lipid metabolism and insulin secretion in a cAMP-dependent manner: implication of its role in the postprandial insulin secretion.A MATLAB tool for pathway enrichment using a topology-based pathway regulation score.Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids.Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells.Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion.Emerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet beta-cell.Analysis of fatty acid composition in insulin secreting cells by comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry.GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.Congenital and environmental factors associated with adipocyte dysregulation as defects of insulin resistance.Orphan nuclear receptors: therapeutic opportunities in skeletal muscle.Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes.Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagonNonalcoholic Steatohepatitis (NASH) Is Associated with a Decline in Pancreatic Beta Cell (β-Cell) Function.PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion.Liraglutide prevents fast weight gain and β-cell dysfunction in male catch-up growth ratsFatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms.CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin+ cells.Fatty acids increase neuronal hypertrophy of Pten knockdown neurons.Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes.Regulation of calcium in pancreatic α- and β-cells in health and disease.Diabetes mellitus and the β cell: the last ten years.Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists.Diabetes and beta cell function: from mechanisms to evaluation and clinical implications.Beta cell response to nutrient overload involves phospholipid remodelling and lipid peroxidation.
P2860
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P2860
Fatty acid metabolism and insulin secretion in pancreatic beta cells.
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Fatty acid metabolism and insulin secretion in pancreatic beta cells.
@ast
Fatty acid metabolism and insulin secretion in pancreatic beta cells.
@en
type
label
Fatty acid metabolism and insulin secretion in pancreatic beta cells.
@ast
Fatty acid metabolism and insulin secretion in pancreatic beta cells.
@en
prefLabel
Fatty acid metabolism and insulin secretion in pancreatic beta cells.
@ast
Fatty acid metabolism and insulin secretion in pancreatic beta cells.
@en
P1433
P1476
Fatty acid metabolism and insulin secretion in pancreatic beta cells.
@en
P2093
P2888
P304
P356
10.1007/S00125-003-1207-4
P577
2003-09-12T00:00:00Z