Selective inhibition of MBNL1-CCUG interaction by small molecules toward potential therapeutic agents for myotonic dystrophy type 2 (DM2)

Selective inhibition of MBNL1-CCUG interaction by small molecules toward potential therapeutic agents for myotonic dystrophy type 2 (DM2)

Item
http://www.wikidata.org/entity/Q35468472
A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophyMyotonic dystrophy: is a narrow focus obscuring the rest of the field?Structural studies of CNG repeatsExamining the interactions of the splicing factor MBNL1 with target RNA sequences via a label-free, multiplex methodStructure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity.Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor.Reducing levels of toxic RNA with small moleculesMBNL proteins and their target RNAs, interaction and splicing regulation.Novel insights of structure-based modeling for RNA-targeted drug discovery.Small molecules that target the toxic RNA in myotonic dystrophy type 2.From dynamic combinatorial 'hit' to lead: in vitro and in vivo activity of compounds targeting the pathogenic RNAs that cause myotonic dystrophy.In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models.Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts.Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules.Synthetic RNA recognition motifs that selectively recognize HIV-1 trans-activation response element hairpin RNA.RNA biology of disease-associated microsatellite repeat expansions.
P2860

Selective inhibition of MBNL1-CCUG interaction by small molecules toward potential therapeutic agents for myotonic dystrophy type 2 (DM2)

Item
http://www.wikidata.org/entity/Q35468472
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Selective inhibition of MBNL1- ...... yotonic dystrophy type 2 (DM2)
@ast
Selective inhibition of MBNL1- ...... yotonic dystrophy type 2 (DM2)
@en
type
label
Selective inhibition of MBNL1- ...... yotonic dystrophy type 2 (DM2)
@ast
Selective inhibition of MBNL1- ...... yotonic dystrophy type 2 (DM2)
@en
prefLabel
Selective inhibition of MBNL1- ...... yotonic dystrophy type 2 (DM2)
@ast
Selective inhibition of MBNL1- ...... yotonic dystrophy type 2 (DM2)
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
Selective inhibition of MBNL1- ...... yotonic dystrophy type 2 (DM2)
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932