Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin. - Wikidata - awgldk - TriplyDB

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.

http://www.wikidata.org/entity/Q35518170

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Multiple Aspects of Gene Dysregulation in Huntington's Disease Landscape of Pin1 in the cell cycle A neuroprotective phase precedes striatal degeneration upon nucleolar stress.Dynamic regulation of Pin1 expression and function during zebrafish development.Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis.Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis.CAG expansion induces nucleolar stress in polyglutamine diseases.Effects of Pin1 Loss in Hdh(Q111) Knock-in Mice.Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation.Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage.Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast.ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair.PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model β-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38(MAPK)-p53 Signaling Pathway.A link between chromatin condensation mechanisms and Huntington's disease: connecting the dots.DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations.HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop.The prolyl-isomerase Pin1 activates the mitochondrial death program of p53 Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes?Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis.Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes.Inhibition of autophagy via p53-mediated disruption of ULK1 in a SCA7 polyglutamine disease model.Transcriptional Dysregulation and Post-translational Modifications in Polyglutamine Diseases: From Pathogenesis to Potential Therapeutic Strategies.Pin1 Modulation in Physiological Status and Neurodegeneration. Any Contribution to the Pathogenesis of Type 3 Diabetes?

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Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.

http://www.wikidata.org/entity/Q35518170

description

2011 nî lūn-bûn

@nan

2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

@wuu

name

Ser46 phosphorylation and prol ...... induced by mutant huntingtin.

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Ser46 phosphorylation and prol ...... induced by mutant huntingtin.

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type

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Ser46 phosphorylation and prol ...... induced by mutant huntingtin.

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Ser46 phosphorylation and prol ...... induced by mutant huntingtin.

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prefLabel

Ser46 phosphorylation and prol ...... induced by mutant huntingtin.

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Ser46 phosphorylation and prol ...... induced by mutant huntingtin.

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PNAS.1106198108

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Ser46 phosphorylation and prol ...... s induced by mutant huntingtin

@en

P2093

Alice Grison

http://www.w3.org/2001/XMLSchema#string

Anna Comel

http://www.w3.org/2001/XMLSchema#string

Elena Agostoni

http://www.w3.org/2001/XMLSchema#string

Fiamma Mantovani

http://www.w3.org/2001/XMLSchema#string

Francesca Persichetti

http://www.w3.org/2001/XMLSchema#string

Stefano Gustincich

http://www.w3.org/2001/XMLSchema#string

P2860

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

Pin1 regulates the timing of mammalian primordial germ cell proliferation

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

Blinded by the Light: The Growing Complexity of p53

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10.1073/PNAS.1106198108

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44

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108

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Giannino Del Sal

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2011-10-19T00:00:00Z

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22011578

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