Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway - Wikidata - awgldk - TriplyDB

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

http://www.wikidata.org/entity/Q33737801

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p73: a Positive or Negative Regulator of Angiogenesis, or Both?Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis DNA repair and aging: the impact of the p53 family Structural Basis for ASPP2 Recognition by the Tumor Suppressor p73 The p53 circuit board A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma.Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.p63 transcriptionally regulates the expression of matrix metallopeptidase 13.{Delta}Np73{beta} puts the brakes on DNA repair.Suppression of acetylpolyamine oxidase by selected AP-1 members regulates DNp73 abundance: mechanistic insights for overcoming DNp73-mediated resistance to chemotherapeutic drugs Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets.The role of mutant p53 in human cancer.p53 Isoforms: An Intracellular Microprocessor?p53 Family and Cellular Stress Responses in Cancer.ΔNp73 enhances promoter activity of TGF-β induced genes.p73 regulates maintenance of neural stem cell.TAp73 induction by nitric oxide: regulation by checkpoint kinase 1 (CHK1) and protection against apoptosis.p73: a multifunctional protein in neurobiology Proinflammatory cytokines and bile acids upregulate ΔNp73 protein, an inhibitor of p53 and p73 tumor suppressors.PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition.TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity.TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation.p73 in Cancer.TAp73 promotes anabolism While p73 is essential, p63 is completely dispensable for the development of the central nervous system p53 Family: Role of Protein Isoforms in Human Cancer.The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation.Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress.Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.microRNA-34a regulates neurite outgrowth, spinal morphology, and function p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis.Interplay between TAp73 Protein and Selected Activator Protein-1 (AP-1) Family Members Promotes AP-1 Target Gene Activation and Cellular Growth.P73 tumor suppressor and its targets, p21 and PUMA, are required for madin-darby canine kidney cell morphogenesis by maintaining an appropriate level of epithelial to mesenchymal transition Mammary epithelial cell polarity is regulated differentially by p73 isoforms via epithelial-to-mesenchymal transition.N-(phosphonacetyl)-L-aspartate induces TAp73-dependent apoptosis by modulating multiple Bcl-2 proteins: potential for cancer therapy.TAp73 transcriptionally represses BNIP3 expression.Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma.Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells.TAp73 depletion accelerates aging through metabolic dysregulation

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Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

http://www.wikidata.org/entity/Q33737801

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2010 nî lūn-bûn

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Isoform-specific p73 knockout ...... he DNA damage response pathway

@ast

Isoform-specific p73 knockout ...... he DNA damage response pathway

@en

type

label

Isoform-specific p73 knockout ...... he DNA damage response pathway

@ast

Isoform-specific p73 knockout ...... he DNA damage response pathway

@en

prefLabel

Isoform-specific p73 knockout ...... he DNA damage response pathway

@ast

Isoform-specific p73 knockout ...... he DNA damage response pathway

@en

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Genes & Development

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Isoform-specific p73 knockout ...... he DNA damage response pathway

@en

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Alessandro Rufini

http://www.w3.org/2001/XMLSchema#string

Andrew Wakeham

http://www.w3.org/2001/XMLSchema#string

Annick Itie-Youten

http://www.w3.org/2001/XMLSchema#string

David R Kaplan

http://www.w3.org/2001/XMLSchema#string

Freda D Miller

http://www.w3.org/2001/XMLSchema#string

Gerry Melino

http://www.w3.org/2001/XMLSchema#string

Katsuya Tsuchihara

http://www.w3.org/2001/XMLSchema#string

Marie Arsenian-Henriksson

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Monica K Wetzel

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Satoshi Inoue

http://www.w3.org/2001/XMLSchema#string

P2860

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor.

Regulation of p53 function and stability by phosphorylation

p73 is required for survival and maintenance of CNS neurons

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

Enhanced phosphorylation of p53 by ATM in response to DNA damage

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

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549-560

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scholarly article

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10.1101/GAD.1873910

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6

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24

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Richard Tomasini

Margareta Wilhelm

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2010-03-01T00:00:00Z

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41656554

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20194434

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2841333

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