The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly.
about
TIP150 interacts with and targets MCAK at the microtubule plus endsThe kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.The far C-terminus of MCAK regulates its conformation and spindle pole focusing.Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its functionPhosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches.Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule associationMCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes.Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interactionHow kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays.Control of MCAK degradation and removal from centromeresPLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activityNup98 regulates bipolar spindle assembly through association with microtubules and opposition of MCAK.Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.Expression and characterization of three Aurora kinase C splice variants found in human oocytesKinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regenerationVisualisation of a kinesin-13 motor on microtubule end mimics.Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.A new model for binding of kinesin 13 to curved microtubule protofilamentsKinesin-13s in mitosis: Key players in the spatial and temporal organization of spindle microtubules.Intrinsic Disorder in the Kinesin Superfamily.The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization.Polo-like kinase 1 regulates the stability of the mitotic centromere-associated kinesin in mitosis.MCAK associates with EB1.The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch.The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition.Kif2 localizes to a subdomain of cortical endoplasmic reticulum that drives asymmetric spindle position.A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition.Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.
P2860
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P2860
The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly.
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The interplay of the N- and C- ...... activity and spindle assembly.
@ast
The interplay of the N- and C- ...... activity and spindle assembly.
@en
type
label
The interplay of the N- and C- ...... activity and spindle assembly.
@ast
The interplay of the N- and C- ...... activity and spindle assembly.
@en
prefLabel
The interplay of the N- and C- ...... activity and spindle assembly.
@ast
The interplay of the N- and C- ...... activity and spindle assembly.
@en
P2093
P2860
P356
P1476
The interplay of the N- and C- ...... activity and spindle assembly.
@en
P2093
Claire E Walczak
Kathleen M Hertzer
Mill W Miller
Stephanie C Ems-McClung
P2860
P304
P356
10.1091/MBC.E06-08-0724
P577
2006-11-08T00:00:00Z