PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity - Wikidata - awgldk - TriplyDB

PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity

PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity

http://www.wikidata.org/entity/Q34509576

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Regulation of localization and activity of the microtubule depolymerase MCAK The KLP-7 Residue S546 Is a Putative Aurora Kinase Site Required for Microtubule Regulation at the Centrosome in C. elegans The far C-terminus of MCAK regulates its conformation and spindle pole focusing.Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation.Phosphorylation of SKAP by GSK3β ensures chromosome segregation by a temporal inhibition of Kif2b activity.The 68-kDa telomeric repeat binding factor 1 (TRF1)-associated protein (TAP68) interacts with and recruits TRF1 to the spindle pole during mitosis Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interaction The spatiotemporal dynamics of chromatin protein HP1α is essential for accurate chromosome segregation during cell division.Five factors can reconstitute all three phases of microtubule polymerization dynamics.A unique insertion in STARD9's motor domain regulates its stability Evolution: functional evolution of nuclear structure.CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.SUV39H1 orchestrates temporal dynamics of centromeric methylation essential for faithful chromosome segregation in mitosis.EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization DDA3 associates with microtubule plus ends and orchestrates microtubule dynamics and directional cell migration.Regulation of a dynamic interaction between two microtubule-binding proteins, EB1 and TIP150, by the mitotic p300/CBP-associated factor (PCAF) orchestrates kinetochore microtubule plasticity and chromosome stability during mitosis The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK.The dynamic cytoskeleton of the developing male germ cell.Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles.The molecular basis for kinesin functional specificity during mitosis.Intrinsic Disorder in the Kinesin Superfamily.Molecular insight into the regulation and function of MCAK.Fyn Accelerates M Phase Progression by Promoting the Assembly of Mitotic Spindle Microtubules.Functional analysis of phosphorylation of the mitotic centromere-associated kinesin by Aurora B kinase in human tumor cells Polo-like kinase 1 regulates the stability of the mitotic centromere-associated kinesin in mitosis.The equilibrium of ubiquitination and deubiquitination at PLK1 regulates sister chromatid separation.Mitotic centromere-associated kinase (MCAK/Kif2C) regulates cellular senescence in human primary cells through a p53-dependent pathway.Localized Aurora B activity spatially controls non-kinetochore microtubules during spindle assembly.A 3'UTR polymorphism modulates mRNA stability of the oncogene and drug target Polo-like Kinase 1.The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch.The activity regulation of the mitotic centromere-associated kinesin by Polo-like kinase 1 A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition.Tumor suppressor protein p53-mediated repression of human mitotic centromere-associated kinesin gene expression is exerted via down-regulation of Sp1 level.

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P2860

PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity

http://www.wikidata.org/entity/Q34509576

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

PLK1 phosphorylates mitotic ce ...... otes its depolymerase activity

@ast

PLK1 phosphorylates mitotic ce ...... otes its depolymerase activity

@en

PLK1 phosphorylates mitotic ce ...... otes its depolymerase activity

@nl

type

label

PLK1 phosphorylates mitotic ce ...... otes its depolymerase activity

@ast

PLK1 phosphorylates mitotic ce ...... otes its depolymerase activity

@en

PLK1 phosphorylates mitotic ce ...... otes its depolymerase activity

@nl

prefLabel

PLK1 phosphorylates mitotic ce ...... otes its depolymerase activity

@ast

PLK1 phosphorylates mitotic ce ...... otes its depolymerase activity

@en

PLK1 phosphorylates mitotic ce ...... otes its depolymerase activity

@nl

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JBC.M110.165340

P1433

Journal of Biological Chemistry

P1476

PLK1 phosphorylates mitotic ce ...... otes its depolymerase activity

@en

P2093

Felix Aikhionbare

http://www.w3.org/2001/XMLSchema#string

Feng Yan

http://www.w3.org/2001/XMLSchema#string

Guowei Fang

http://www.w3.org/2001/XMLSchema#string

Hai Hou

http://www.w3.org/2001/XMLSchema#string

Hengyi Shao

http://www.w3.org/2001/XMLSchema#string

Mei Zhu

http://www.w3.org/2001/XMLSchema#string

Xia Ding

http://www.w3.org/2001/XMLSchema#string

Xuebiao Yao

http://www.w3.org/2001/XMLSchema#string

Youjun Chu

http://www.w3.org/2001/XMLSchema#string

Yuejia Huang

http://www.w3.org/2001/XMLSchema#string

P2860

The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly

TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly

Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments

Aurora B regulates MCAK at the mitotic centromere

Genome stability is ensured by temporal control of kinetochore-microtubule dynamics

Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors

TIP150 interacts with and targets MCAK at the microtubule plus ends

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

Mitotic centromere-associated kinesin is important for anaphase chromosome segregation

A standardized kinesin nomenclature

P304

3033-3046

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scholarly article

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10.1074/JBC.M110.165340

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4

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286

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2010-11-15T00:00:00Z

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21078677

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phosphorylation

P932

3024797

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