MCAK associates with the tips of polymerizing microtubules
about
TIP150 interacts with and targets MCAK at the microtubule plus endsRegulation of localization and activity of the microtubule depolymerase MCAKThe kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignmentThe kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.Examination of actin and microtubule dependent APC localisations in living mammalian cells.+TIPs: SxIPping along microtubule endsDivergent microtubule assembly rates after short- versus long-term loss of end-modulating kinesins.The far C-terminus of MCAK regulates its conformation and spindle pole focusing.TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylationPlus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle.Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAKTubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends.The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear rolesAurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its functionDeciphering protein function during mitosis in PtK cells using RNAi.Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites.Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches.Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis.Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance.Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule associationRac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cells.Probing microtubule polymerisation state at single kinetochores during metaphase chromosome motionSpatial regulation of astral microtubule dynamics by Kif18B in PtK cells.A perikinetochoric ring defined by MCAK and Aurora-B as a novel centromere domain.MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes.Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.MCAK-mediated regulation of endothelial cell microtubule dynamics is mechanosensitive to myosin-II contractility.How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays.Long astral microtubules uncouple mitotic spindles from the cytokinetic furrowMCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment.Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAKA unique kinesin-8 surface loop provides specificity for chromosome alignmentPLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activityNucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly.Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.EB1-recruited microtubule +TIP complexes coordinate protrusion dynamics during 3D epithelial remodeling.Cyc17, a meiosis-specific cyclin, is essential for anaphase initiation and chromosome segregation in Tetrahymena thermophila.Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.
P2860
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P2860
MCAK associates with the tips of polymerizing microtubules
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
MCAK associates with the tips of polymerizing microtubules
@ast
MCAK associates with the tips of polymerizing microtubules
@en
MCAK associates with the tips of polymerizing microtubules
@nl
type
label
MCAK associates with the tips of polymerizing microtubules
@ast
MCAK associates with the tips of polymerizing microtubules
@en
MCAK associates with the tips of polymerizing microtubules
@nl
prefLabel
MCAK associates with the tips of polymerizing microtubules
@ast
MCAK associates with the tips of polymerizing microtubules
@en
MCAK associates with the tips of polymerizing microtubules
@nl
P2093
P2860
P3181
P356
P1476
MCAK associates with the tips of polymerizing microtubules
@en
P2093
Ayana T Moore
Didier Job
George von Dassow
Kathleen E Rankin
Leticia Peris
Michael Wagenbach
Yulia Ovechkina
P2860
P3181
P356
10.1083/JCB.200411089
P407
P577
2005-05-09T00:00:00Z