Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.
about
Evaluation of traditional medicines for neurodegenerative diseases using Drosophila modelsDirect inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.In silico modeling predicts drug sensitivity of patient-derived cancer cells.Therapeutic modulators of STAT signalling for human diseasesNegative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells.Knockdown of DNA methyltransferase-1 inhibits proliferation and derepresses tumor suppressor genes in myeloma cells.Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivativesOverexpression of caudal type homeobox transcription factor 2 inhibits the growth of the MGC-803 human gastric cancer cell line in vivo.Dietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network.Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells.Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.Pentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and phosphorylation of p65.Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss.Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse modelTripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents.Dietary phytochemicals alter epigenetic events and signaling pathways for inhibition of metastasis cascade: phytoblockers of metastasis cascade.A Review: Phytochemicals Targeting JAK/STAT Signaling and IDO Expression in Cancer.Analysis of the intricate relationship between chronic inflammation and cancer.New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-κB transcription factors.Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase.Control of autoimmune inflammation by celastrol, a natural triterpenoid.PI3KCA plays a major role in multiple myeloma and its inhibition with BYL719 decreases proliferation, synergizes with other therapies and overcomes stroma-induced resistance.Celastrol inhibits lipopolysaccharide-induced angiogenesis by suppressing TLR4-triggered nuclear factor-kappa B activation.β-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase.Celastrol: A Spectrum of Treatment Opportunities in Chronic DiseasesPredictive simulation approach for designing cancer therapeutic regimens with novel biological mechanisms.Celastrol inhibits migration and invasion through blocking the NF-κB pathway in ovarian cancer cells.Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo.Celastrol and Its Role in Controlling Chronic Diseases.Chemopreventive activity of celastrol in drug-resistant human colon carcinoma cell cultures.Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade.Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma.A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F.YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cellsThe Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies
P2860
Q27027455-A3B56424-4AAD-427C-A8B1-3F8D0344E9C1Q30278518-638D3F19-8EAC-4AB7-9740-26C7B6A52FA0Q33646338-C3EC7F29-8407-47DD-B7F7-1D8C21569DB1Q33684732-FED8D772-6C28-43EE-B006-C2A308584A90Q34283730-22D1C01A-680C-4F7F-A63F-C8B5EF5729CBQ34293113-E5D25CAC-D590-4013-AEB6-DB05A50A8B2AQ34441998-C932E9D4-4E49-44ED-A506-2F2B1C67BEBCQ35628358-541819B4-875B-4975-B568-277328319EAFQ35863370-01A50BDF-3378-4210-B787-B34060BFA76DQ35883602-E38D425A-BBAD-4588-B5C4-566E1C185294Q36368271-44D87260-777E-4518-B8E5-7A01BE3AEFCFQ36744894-DF7E3CB2-C9ED-4559-9120-AD937138CB5BQ37589832-34A8046A-F0BE-4324-8AE0-D60E987752B7Q37718435-A04820B5-D77B-4224-A86F-22639EF4B8D0Q37915623-B893A7AE-29BA-4F27-B73E-CAA66C014F4EQ38175845-464D6248-9480-4BCC-9C3F-5EC57D91B63EQ38383263-8AEEB113-13DE-43C1-9B63-7DA968879DC2Q38458724-1ACBCF4D-1323-4023-A360-751D051CD7B4Q38696518-E2689A6C-ACCC-4E51-A0B2-A2CC63107075Q38716136-F01D44D6-0CE2-473A-B7C0-9FB175289DDEQ38894091-BBA40BF0-8DE0-4B14-8CDB-5BFF8203F4C4Q39036088-1BFE8CDA-A669-4000-8F1D-F6BBA51809A3Q39070877-0EB99BF6-6342-4BC3-A65E-085B79BEAFE3Q39139874-EA185FF1-CF5D-48DB-A14D-7AC902CD2784Q39406168-5464B724-0F7B-4D43-A4C0-A9ADC3606D12Q39765453-B5905D8C-0BF0-4704-BFBE-2F5A9027AF47Q41016182-F1CF7E8C-17DA-4745-8707-B623D3DFEB2EQ48808585-7C1FE4BC-ED06-4515-B66B-1B4A1FEB9A1FQ51458495-F22B1501-F817-4791-8A85-5D081BE13BE0Q53681639-D814DFDF-610C-4EDD-A22F-7DA452D00551Q55049042-D1554C29-5661-43DF-9124-6E1BEE876807Q55281764-F38CCA57-BD6F-4A88-A720-35913A6863F3Q55407628-72BE1555-134B-4727-8BBF-FBC5C014ED29Q57298079-8ADFED23-5A72-46A7-8821-2F6B364EC4A3Q58742654-DA914CE1-77A3-44AA-BCB9-A07EC541B183
P2860
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Celastrol inhibits proliferati ...... cts in multiple myeloma cells.
@ast
Celastrol inhibits proliferati ...... cts in multiple myeloma cells.
@en
type
label
Celastrol inhibits proliferati ...... cts in multiple myeloma cells.
@ast
Celastrol inhibits proliferati ...... cts in multiple myeloma cells.
@en
prefLabel
Celastrol inhibits proliferati ...... cts in multiple myeloma cells.
@ast
Celastrol inhibits proliferati ...... cts in multiple myeloma cells.
@en
P2093
P2860
P1476
Celastrol inhibits proliferati ...... ucts in multiple myeloma cells
@en
P2093
Alan Prem Kumar
Ashish Sharma
Hui Sin Hay
Muthu K Shanmugam
Radhamani Kannaiyan
Shireen Vali
Shweta Kapoor
Taher Abbasi
Wee-Joo Chng
P2860
P304
P356
10.1111/J.1476-5381.2011.01449.X
P407
P577
2011-11-01T00:00:00Z