Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.
about
There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative DiseasesNeurodegeneration and microtubule dynamics: death by a thousand cutsThe synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degenerationEpigenetics of Alzheimer's disease and frontotemporal dementiaModeling the complex pathology of Alzheimer's disease in DrosophilaDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseInteractions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.Tau promotes neurodegeneration through global chromatin relaxation.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesLoss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.Drosophila melanogaster as a model organism for Alzheimer's disease.Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila.A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis.Expression of 1N3R-Tau isoform inhibits cell proliferation by inducing S phase arrest in N2a cells.Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster.Drosophila models of tauopathies: what have we learned?Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative diseaseMembrane trafficking in neuronal maintenance and degeneration.Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms.Protein phosphorylation in neurodegeneration: friend or foe?Invited review: Animal models of tauopathies and their implications for research/translation into the clinic.Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models.ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer's disease.Autophagy and Human Neurodegenerative Diseases-A Fly's Perspective.Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death.ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity.Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau.Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2.Drosophila as a screening tool to study human neurodegenerative diseases.Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies.Identification of Tau Toxicity Modifiers in the Drosophila Eye.Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?Phenotypic differences between Drosophila Alzheimer’s disease models expressing human Aβ42 in the developing eye and brain
P2860
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P2860
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Functional genomic screen and ...... ated from tau phosphorylation.
@ast
Functional genomic screen and ...... ated from tau phosphorylation.
@en
type
label
Functional genomic screen and ...... ated from tau phosphorylation.
@ast
Functional genomic screen and ...... ated from tau phosphorylation.
@en
prefLabel
Functional genomic screen and ...... ated from tau phosphorylation.
@ast
Functional genomic screen and ...... ated from tau phosphorylation.
@en
P2860
P356
P1476
Functional genomic screen and ...... ated from tau phosphorylation.
@en
P2093
George R Jackson
Surendra S Ambegaokar
P2860
P304
P356
10.1093/HMG/DDR432
P577
2011-09-23T00:00:00Z