Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms.
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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's diseaseGenes associated with Alzheimer's disease: an overview and current statusLate-Onset Alzheimer's Disease Genes and the Potentially Implicated PathwaysDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseEffects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model.Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population.Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's diseaseTargeting axonal protein synthesis in neuroregeneration and degeneration.Fruit flies in biomedical research.Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease.The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity.Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese populationGenetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba NigeriansThe Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity.Drosophila and experimental neurology in the post-genomic era.FERMT2 rs17125944 polymorphism with Alzheimer's disease risk: a replication and meta-analysis.The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism.Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits.Alzheimer's disease genetics: from the bench to the clinic.Common and Rare Genetic Variants Associated With Alzheimer's Disease.Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models.Novel susceptibility loci for Alzheimer's disease.All-trans retinoic acid up-regulates the human CD2AP gene expression through Sp1/Sp3 binding sites.Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies.Regulation of neuronal gene expression by local axonal translation.The C-terminus of tau protein plays an important role in its stability and toxicity.miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer's diseaseBin1 directly remodels actin dynamics through its BAR domain.A Novel Genetic Screen Identifies Modifiers of Age-Dependent Amyloid β Toxicity in the Drosophila Brain.Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity.Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions.Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression.iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.Insights into amyloid disease from fly models.Alzheimer's Disease: From Genetic Variants to the Distinct Pathological Mechanisms.Genetic Biomarkers on Age-Related Cognitive Decline.JNK is antagonized to ensure the correct number of interommatidial cells pattern the Drosophila retina.Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis.
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Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 25 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Functional screening in Drosop ...... cates Tau-mediated mechanisms.
@en
Functional screening in Drosop ...... cates Tau-mediated mechanisms.
@nl
type
label
Functional screening in Drosop ...... cates Tau-mediated mechanisms.
@en
Functional screening in Drosop ...... cates Tau-mediated mechanisms.
@nl
prefLabel
Functional screening in Drosop ...... cates Tau-mediated mechanisms.
@en
Functional screening in Drosop ...... cates Tau-mediated mechanisms.
@nl
P2093
P2860
P356
P1476
Functional screening in Drosop ...... cates Tau-mediated mechanisms.
@en
P2093
Allison Diamond
Danelle Devenport
Joshua M Shulman
Lori B Chibnik
Martin P Powers
Mel B Feany
Nicholas H Brown
Nikolaos Giagtzoglou
Philip L De Jager
Portia Chipendo
P2860
P304
P356
10.1093/HMG/DDT478
P577
2013-09-25T00:00:00Z