Identification of functional regions on the I-Ab molecule by site-directed mutagenesis.
about
Point mutations define positions in HLA-DR3 molecules that affect antigen presentation.Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal bA single base mutation in an I-A alpha-chain gene alters T-cell recognition.Expression of human class II major histocompatibility complex antigens using retrovirus vectors.Allele-specific control of Ia molecule surface expression and conformation: implications for a general model of Ia structure-function relationshipsT cell clones specific for an amphipathic alpha-helical region of sperm whale myoglobin show differing fine specificities for synthetic peptides. A multiview/single structure interpretation of immunodominanceIdentification of an immunodominant region on the I-A beta chain using site-directed mutagenesis and DNA-mediated gene transfer.Structural mutation affecting intracellular transport and cell surface expression of murine class II moleculesFunctional polymorphism of each of the two HLA-DR beta chain loci demonstrated with antigen-specific DR3- and DRw52-restricted T cell clones.The role of polymorphic I-Ak beta chain residues in presentation of a peptide from myelin basic protein.The contribution of mutant amino acids to alloantigenicity.DNA sequence analysis of I-Ak beta mutants reveals serologically immunodominant region.Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptorsT cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.
P2860
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P2860
Identification of functional regions on the I-Ab molecule by site-directed mutagenesis.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Identification of functional regions on the I-Ab molecule by site-directed mutagenesis.
@ast
Identification of functional regions on the I-Ab molecule by site-directed mutagenesis.
@en
type
label
Identification of functional regions on the I-Ab molecule by site-directed mutagenesis.
@ast
Identification of functional regions on the I-Ab molecule by site-directed mutagenesis.
@en
prefLabel
Identification of functional regions on the I-Ab molecule by site-directed mutagenesis.
@ast
Identification of functional regions on the I-Ab molecule by site-directed mutagenesis.
@en
P2093
P2860
P356
P1476
Identification of functional regions on the I-Ab molecule by site-directed mutagenesis.
@en
P2093
J G Seidman
L H Glimcher
R A Waldmann
P2860
P304
P356
10.1073/PNAS.83.3.747
P407
P577
1986-02-01T00:00:00Z