Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase
about
Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threatStructural and Biochemical Evidence That a TEM-1 -Lactamase N170G Active Site Mutant Acts via Substrate-assisted CatalysisInsights into -Lactamases from Burkholderia Species, Two Phylogenetically Related yet Distinct Resistance DeterminantsA triple mutant in the Ω-loop of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysisExploring the role of a conserved class A residue in the Ω-Loop of KPC-2 β-lactamase: a mechanism for ceftazidime hydrolysisInvestigating and Engineering Enzymes by Genetic Selection.Combinatorial codon-based amino acid substitutions.Engineering a regulatable enzyme for homogeneous immunoassays.Roles of amino acids 161 to 179 in the PSE-4 omega loop in substrate specificity and in resistance to ceftazidimeCharacterization of a PSE-4 mutant with different properties in relation to penicillanic acid sulfones: importance of residues 216 to 218 in class A beta-lactamases.RNA mutagenesis yields highly diverse mRNA libraries for in vitro protein evolution.A new family of cyanobacterial penicillin-binding proteins. A missing link in the evolution of class A beta-lactamases.Contribution of natural amino acid substitutions in SHV extended-spectrum beta-lactamases to resistance against various beta-lactams.SHV-16, a beta-lactamase with a pentapeptide duplication in the omega loop.The tandem repeats enabling reversible switching between the two phases of β-lactamase substrate spectrum.Circular permutation in the Ω-loop of TEM-1 β-lactamase results in improved activity and altered substrate specificityAmino acid substitutions at Ambler position Gly238 in the SHV-1 beta-lactamase: exploring sequence requirements for resistance to penicillins and cephalosporins.Evolution of extended-spectrum beta-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia.Antibiotic resistance in primary and persistent endodontic infectionsActivity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop.Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime.High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A β-lactamase, PenL.Exploring the Role of the Ω-Loop in the Evolution of Ceftazidime Resistance in the PenA β-Lactamase from Burkholderia multivorans, an Important Cystic Fibrosis PathogenProtein evolution by codon-based random deletions.Selection of naturally occurring extended-spectrum TEM beta-lactamase variants by fluctuating beta-lactam pressure.Development of a sensitive and specific enzyme-linked immunosorbent assay for detecting and quantifying CMY-2 and SHV beta-lactamases.Catalytic properties of class A beta-lactamases: efficiency and diversity.Functional modulation and directed assembly of an enzyme through designed non-natural post-translation modification.Modelling proteins' hidden conformations to predict antibiotic resistance.Kinetic analysis of an inhibitor-resistant variant of the OHIO-1 beta-lactamase, an SHV-family class A enzymeStructural studies of the mechanism for biosensing antibiotics in a fluorescein-labeled β-lactamase.Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4.Structure-function analysis of alpha-helix H4 using PSE-4 as a model enzyme representative of class A beta-lactamases.
P2860
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P2860
Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase
@ast
Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase
@en
type
label
Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase
@ast
Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase
@en
prefLabel
Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase
@ast
Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase
@en
P2860
P1476
Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase
@en
P2093
J F Petrosino
T Palzkill
P2860
P304
P356
10.1128/JB.178.7.1821-1828.1996
P407
P577
1996-04-01T00:00:00Z