Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling - Wikidata - awgldk - TriplyDB

Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling

Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling

http://www.wikidata.org/entity/Q35604403

about

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding Headpiece domain of dematin regulates calcium mobilization and signaling in platelets WNT-3a modulates platelet function by regulating small GTPase activity Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway.The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer.The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism.Rap1-Rac1 circuits potentiate platelet activation Platelet-neutrophil interactions under thromboinflammatory conditions Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis.The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation.Platelets as cellular effectors of inflammation in vascular diseases.Integrin signaling in vascular function.Secrets of platelet exocytosis - what do we really know about platelet secretion mechanisms?Src family kinases: at the forefront of platelet activation RAP1-GTPase signaling and platelet function.New Concepts and Mechanisms of Platelet Activation Signaling.Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis.The Small GTPase Rap1b: A Bidirectional Regulator of Platelet Adhesion Receptors.Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target?The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis.Role of G protein signaling in the formation of the fibrin(ogen)-integrin αIIbβ3-actin cytoskeleton complex in platelets.Effects of riboflavin and ultraviolet light treatment on platelet thrombus formation on collagen via integrin αIIbβ3 activation.Platelet Signaling Pathways and New Inhibitors.GAS6/TAM Pathway Signaling in Hemostasis and Thrombosis.

P2860

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P2860

Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling

http://www.wikidata.org/entity/Q35604403

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Distinct roles for Rap1b prote ...... in αIIbβ3 outside-in signaling

@ast

Distinct roles for Rap1b prote ...... in αIIbβ3 outside-in signaling

@en

type

label

Distinct roles for Rap1b prote ...... in αIIbβ3 outside-in signaling

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Distinct roles for Rap1b prote ...... in αIIbβ3 outside-in signaling

@en

prefLabel

Distinct roles for Rap1b prote ...... in αIIbβ3 outside-in signaling

@ast

Distinct roles for Rap1b prote ...... in αIIbβ3 outside-in signaling

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JBC.M111.239608

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Journal of Biological Chemistry

P1476

Distinct roles for Rap1b prote ...... in αIIbβ3 outside-in signaling

@en

P2093

Andrew J Morris

http://www.w3.org/2001/XMLSchema#string

Binggang Xiang

http://www.w3.org/2001/XMLSchema#string

Gilbert C White

http://www.w3.org/2001/XMLSchema#string

Guoying Zhang

http://www.w3.org/2001/XMLSchema#string

Magdalena Chrzanowska-Wodnicka

http://www.w3.org/2001/XMLSchema#string

Shaojing Ye

http://www.w3.org/2001/XMLSchema#string

Sidney W Whiteheart

http://www.w3.org/2001/XMLSchema#string

Susan S Smyth

http://www.w3.org/2001/XMLSchema#string

T Kent Gartner

http://www.w3.org/2001/XMLSchema#string

Zhenyu Li

http://www.w3.org/2001/XMLSchema#string

P2860

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

Src kinase activation by direct interaction with the integrin beta cytoplasmic domain

Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.

RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

GPVI and integrin alphaIIb beta3 signaling in platelets

RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs

Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation

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39466-39477

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scholarly article

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10.1074/JBC.M111.239608

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P433

45

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286

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2011-09-22T00:00:00Z

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21940635

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3234770

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