Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
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Leveraging big data to transform target selection and drug discoveryTumor-Derived Cell Lines as Molecular Models of Cancer PharmacogenomicsBiological Networks for Cancer Candidate Biomarkers DiscoveryA genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylationSWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1BAssessment of FBA Based Gene Essentiality Analysis in Cancer with a Fast Context-Specific Network Reconstruction MethodPublic data and open source tools for multi-assay genomic investigation of diseaseScreenBEAM: a novel meta-analysis algorithm for functional genomics screens via Bayesian hierarchical modelingOGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell linesIntegrated genetic and pharmacologic interrogation of rare cancersSMARCE1 regulates metastatic potential of breast cancer cells through the HIF1A/PTK2 pathwayCorrelating chemical sensitivity and basal gene expression reveals mechanism of action.Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.Drug repurposing from the perspective of pharmaceutical companies.SoFIA: a data integration framework for annotating high-throughput datasets.Minimizing bias in target selection by exploiting multidisciplinary Big Data and the protein interactome.Data sources for in vivo molecular profiling of human phenotypes.Gene regulatory pattern analysis reveals essential role of core transcriptional factors' activation in triple-negative breast cancer.Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data.Systematic genomic and translational efficiency studies of uveal melanoma.Synergistic interactions with PI3K inhibition that induce apoptosis.Identification and characterization of essential genes in the human genome.Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.A genetic basis for the variation in the vulnerability of cancer to DNA damage.Induced protein degradation: an emerging drug discovery paradigm.Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screeningComputational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer.Enrichr: a comprehensive gene set enrichment analysis web server 2016 update.Evaluation of drug-targetable genes by defining modes of abnormality in gene expression.Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine.Challenges in identifying cancer genes by analysis of exome sequencing data.Transcriptome Analysis Identifies the Dysregulation of Ultraviolet Target Genes in Human Skin Cancers.Network analysis of gene essentiality in functional genomics experiments.MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development.USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy.Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines.Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells.Cancer genomics: opportunities for medicinal chemistry?
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P2860
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Parallel genome-scale loss of ...... specific genetic dependencies.
@ast
Parallel genome-scale loss of ...... specific genetic dependencies.
@en
type
label
Parallel genome-scale loss of ...... specific genetic dependencies.
@ast
Parallel genome-scale loss of ...... specific genetic dependencies.
@en
altLabel
Parallel genome-scale loss of ...... -specific genetic dependencies
@en
prefLabel
Parallel genome-scale loss of ...... specific genetic dependencies.
@ast
Parallel genome-scale loss of ...... specific genetic dependencies.
@en
P2093
P2860
P4510
P50
P356
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P1476
Parallel genome-scale loss of ...... specific genetic dependencies.
@en
P2093
Barbara A Weir
Barbara Hill Meyers
David E Root
David Pellman
Dongkeun Jang
Elizabeth Dwinell
Ellen Gelfand
Glenn S Cowley
Guozhi Jiang
P2860
P2888
P304
P356
10.1038/SDATA.2014.35
P407
P577
2014-09-30T00:00:00Z
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P6179
1045156246