Modeling tau polymerization in vitro: a review and synthesis.
about
The MAP2/Tau family of microtubule-associated proteinsTau and tauopathiesFTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action.The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegenerationTOC1: a valuable tool in assessing disease progression in the rTg4510 mouse model of tauopathy.Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors.Targeting Abeta and tau in Alzheimer's disease, an early interim reportTest and Evaluation of ff99IDPs Force Field for Intrinsically Disordered Proteins.RNA stores tau reversibly in complex coacervatesCombinatorial Tau pseudophosphorylation: markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual partsThe relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's diseaseInhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide cross-linking.Tau phosphorylation, aggregation, and cell toxicityDisease modifying therapy for AD?Tau as a therapeutic target in neurodegenerative disease.New application of beta-galactosidase complementation to monitor tau self-association.Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.Intracellular and extracellular tau.Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.Removal of pattern-breaking sequences in microtubule binding repeats produces instantaneous tau aggregation and toxicity.Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation.GSK-3beta phosphorylation of functionally distinct tau isoforms has differential, but mild effects.Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathiesTau-er of PowerPotential neuroprotective strategies against tauopathy.FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions.New force field on modeling intrinsically disordered proteins.Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation.Linkage-dependent contribution of repeat peptides to self-aggregation of three- or four-repeat microtubule-binding domains in tau protein.Possible role of each repeat structure of the microtubule-binding domain of the tau protein in in vitro aggregation.Amyloidogenesis of Tau protein.Protein Misfolding in Prion and Prion-Like Diseases: Reconsidering a Required Role for Protein Loss-of-Function.Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization.Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation.Regions of tau implicated in the paired helical fragment core as defined by NMR.Electrochemical investigations of Tau protein phosphorylations and interactions with Pin1.Phosphorylation modulates the local conformation and self-aggregation ability of a peptide from the fourth tau microtubule-binding repeat
P2860
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P2860
Modeling tau polymerization in vitro: a review and synthesis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Modeling tau polymerization in vitro: a review and synthesis.
@ast
Modeling tau polymerization in vitro: a review and synthesis.
@en
type
label
Modeling tau polymerization in vitro: a review and synthesis.
@ast
Modeling tau polymerization in vitro: a review and synthesis.
@en
prefLabel
Modeling tau polymerization in vitro: a review and synthesis.
@ast
Modeling tau polymerization in vitro: a review and synthesis.
@en
P2093
P356
P1433
P1476
Modeling tau polymerization in vitro: a review and synthesis.
@en
P2093
Lester I Binder
Robert W Berry
T Chris Gamblin
P304
15009-15017
P356
10.1021/BI035722S
P407
P577
2003-12-01T00:00:00Z