Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation.
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Histone deacetylase 6 interacts with the microtubule-associated protein tauThe Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a CostThe physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernationGenotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tauMammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer diseaseHumanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potencyA caspase cleaved form of tau is preferentially degraded through the autophagy pathway.Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability?Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis.Pseudophosphorylation of tau protein directly modulates its aggregation kinetics.Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases.Caspase activation precedes and leads to tangles.Suppression of autophagy and activation of glycogen synthase kinase 3beta facilitate the aggregate formation of tau.Caspase Cleaved Tau in Alzheimer's Disease: A Therapeutic Target Realized.The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeuticsPre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's diseasePseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms.Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer's disease.Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase?The role of tau in neurodegenerationNew application of beta-galactosidase complementation to monitor tau self-association.Physiological regulation of tau phosphorylation during hibernationThe cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.Presence of a carboxy-terminal pseudorepeat and disease-like pseudohyperphosphorylation critically influence tau's interaction with microtubules in axon-like processes.Tau and neurodegenerative disorders.Physiological and Pathophysiological Implications of Synaptic Tau.Therapeutic Strategies for Restoring Tau Homeostasis.Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.Split GFP complementation assay: a novel approach to quantitatively measure aggregation of tau in situ: effects of GSK3beta activation and caspase 3 cleavage.DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.Activation of glycogen synthase kinase 3beta promotes the intermolecular association of tau. The use of fluorescence resonance energy transfer microscopy.Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants.Adenosine A2A receptor inactivation alleviates early-onset cognitive dysfunction after traumatic brain injury involving an inhibition of tau hyperphosphorylationPseudohyperphosphorylation causing AD-like changes in tau has significant effects on its polymerization.Caspase-mediated truncation of tau potentiates aggregation.Caspase-3-Dependent Proteolytic Cleavage of Tau Causes Neurofibrillary Tangles and Results in Cognitive Impairment During Normal Aging.Tau phosphorylation affects its axonal transport and degradation.Amyloid Beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy.Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.
P2860
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P2860
Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Site-specific phosphorylation ...... eractions and tau aggregation.
@en
type
label
Site-specific phosphorylation ...... eractions and tau aggregation.
@en
prefLabel
Site-specific phosphorylation ...... eractions and tau aggregation.
@en
P2093
P2860
P356
P1476
Site-specific phosphorylation ...... eractions and tau aggregation.
@en
P2093
Gail V W Johnson
Huiping Ding
Tori A Matthews
P2860
P304
19107-19114
P356
10.1074/JBC.M511697200
P407
P577
2006-05-10T00:00:00Z