Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. - Wikidata - awgldk - TriplyDB

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.

http://www.wikidata.org/entity/Q37606284

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Alzheimer mechanisms and therapeutic strategies Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro Novel therapeutics for Alzheimer's disease: an update GSPE interferes with tau aggregation in vivo: implication for treating tauopathy Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets The role of tau in neurodegenerative diseases and its potential as a therapeutic target Tau-targeted treatment strategies in Alzheimer's disease Tau and tauopathies Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice Induced tauopathy in a novel 3D-culture model mediates neurodegenerative processes: a real-time study on biochips The role of mTOR signaling in Alzheimer disease The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier)Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons Brain intraventricular injection of amyloid-β in zebrafish embryo impairs cognition and increases tau phosphorylation, effects reversed by lithium Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies Zebrafish models of Tauopathy Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.Biomarkers in the Diagnosis and Prognosis of Alzheimer's Disease.Roles of tau protein in health and disease.Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer's disease-related signaling.Total and phosphorylated tau protein as biological markers of Alzheimer's disease.Tau mutants bind tubulin heterodimers with enhanced affinity.Potential future neuroprotective therapies for neurodegenerative disorders and stroke.Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice.Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation.Wnt5a evokes cortical axon outgrowth and repulsive guidance by tau mediated reorganization of dynamic microtubules.RTN/Nogo in forming Alzheimer's neuritic plaques.Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice.Data mining of high density genomic variant data for prediction of Alzheimer's disease risk Modeling of age-dependent amyloid accumulation and γ-secretase inhibition of soluble and insoluble Aβ in a transgenic mouse model of amyloid deposition.Advances with RNA interference in Alzheimer's disease research.

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Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.

http://www.wikidata.org/entity/Q37606284

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on October 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.

@en

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.

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type

label

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.

@en

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.

@nl

prefLabel

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.

@en

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.

@nl

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Nature Reviews Drug Discovery

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Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.

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Kurt R Brunden

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Virginia M-Y Lee

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P2860

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

Selectivity and therapeutic inhibition of kinases: to be or not to be?

Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease

Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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783-793

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scholarly article

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10.1038/NRD2959

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10

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8

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John Q. Trojanowski

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2009-10-01T00:00:00Z

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26861051

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19794442

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Alzheimer's disease

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2787232

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