Genetic syndromes in man with potential relevance to the pathobiology of aging.
about
Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.Potent inhibition of werner and bloom helicases by DNA minor groove binding drugsCharacterization of the human and mouse WRN 3'-->5' exonucleaseWerner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activityWRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkThe spectrum of WRN mutations in Werner syndrome patientsA mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminusModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesThe interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNADeletion of Ku86 causes early onset of senescence in micePOLD1 Germline Mutations in Patients Initially Diagnosed with Werner SyndromeGenetic determinants of human health span and life span: progress and new opportunitiesHow Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend InitiativeCharacteristics of adults with down syndrome: prevalence of age-related conditionsWRN polymorphisms affect expression levels of plasminogen activator inhibitor type 1 in cultured fibroblasts.Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential.Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.Rapid purification of helicase proteins and in vitro analysis of helicase activity.Quantitative genetics of postponed aging in Drosophila melanogaster. II. Analysis of selected lines.Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein ADeletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs.Accelerated in vivo epidermal telomere loss in Werner syndrome.Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid featuresLoss of telomeric DNA during aging of normal and trisomy 21 human lymphocytesChromosomal aneuploidy in the aging brain.Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae.Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markersOxidative Stress and Mitochondrial Dysfunction in Down's Syndrome: Relevance to Aging and DementiaWRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations.Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A.Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiaeThe role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging.The Werner syndrome protein is involved in RNA polymerase II transcriptionDNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations.Contributions of DNA interstrand cross-links to aging of cells and organisms.Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.Ethnic-Specific WRN Mutations in South Asian Werner Syndrome Patients: Potential Founder Effect in Patients with Indian or Pakistani Ancestry.The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease
P2860
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P2860
Genetic syndromes in man with potential relevance to the pathobiology of aging.
description
1978 nî lūn-bûn
@nan
1978年の論文
@ja
1978年論文
@yue
1978年論文
@zh-hant
1978年論文
@zh-hk
1978年論文
@zh-mo
1978年論文
@zh-tw
1978年论文
@wuu
1978年论文
@zh
1978年论文
@zh-cn
name
Genetic syndromes in man with potential relevance to the pathobiology of aging.
@ast
Genetic syndromes in man with potential relevance to the pathobiology of aging.
@en
type
label
Genetic syndromes in man with potential relevance to the pathobiology of aging.
@ast
Genetic syndromes in man with potential relevance to the pathobiology of aging.
@en
prefLabel
Genetic syndromes in man with potential relevance to the pathobiology of aging.
@ast
Genetic syndromes in man with potential relevance to the pathobiology of aging.
@en
P1476
Genetic syndromes in man with potential relevance to the pathobiology of aging.
@en
P2093
P577
1978-01-01T00:00:00Z