Mechanism of action of 2-methoxyestradiol: new developments.
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Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levelsAntiangiogenic Steroids in Human Cancer Therapy.Preeclampsia, hypoxia, thrombosis, and inflammationInterleukin-11 protects against renal ischemia and reperfusion injury.Microtubular stability affects cardiomyocyte glycolysis by HIF-1alpha expression and endonuclear aggregation during early stages of hypoxia.2-methoxyestradiol inhibits Barrett's esophageal adenocarcinoma growth and differentiation through differential regulation of the beta-catenin-E-cadherin axisPhase I trial of 2-methoxyestradiol NanoCrystal dispersion in advanced solid malignancies.A phase II study of 2-methoxyestradiol (2ME2) NanoCrystal® dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC).The World Health Organization defines hormone replacement therapy as carcinogenic: is this plausible?Effects of hormone deprivation and 2-methoxyestradiol combination therapy on hormone-dependent prostate cancer in vivo.Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD).Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts.A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer.Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells.A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate.Promoting endothelial function by S-nitrosoglutathione through the HIF-1α/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats.Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell lineInhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury.Genotoxic Damage to Glioblastoma Cells Treated with 6 MV X-Radiation in The Presence or Absence of Methoxy Estradiol, IUDR or Topotecan.Effect of tumour necrosis factor-alpha on estrogen metabolic pathways in breast cancer cells.Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.Recent Advances in Targeting Tumor Energy Metabolism with Tumor Acidosis as a Biomarker of Drug Efficacy.Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor.Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee jointsEffect of tumor necrosis factor-alpha on estrogen metabolism and endometrial cells: potential physiological and pathological relevance.Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol, and a radiosynthesis of 2-[(18)F]fluoroethoxyestradiol for positron emission tomography.Molecular crosstalk between apoptosis and autophagy induced by a novel 2-methoxyestradiol analogue in cervical adenocarcinoma cells.Estradiol 17β and its metabolites stimulate cell proliferation and antagonize ascorbic acid-suppressed cell proliferation in human ovarian cancer cellsTargeting the hypoxia-inducible factor (HIF) pathway in cancer.Flavonoid-induced glutathione depletion: potential implications for cancer treatmentOxidative stress and therapeutic opportunities: focus on the Ewing's sarcoma family of tumors.2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential.Inhibition of proliferation and invasion in 2D and 3D models by 2-methoxyestradiol in human melanoma cells.2-hydroxyoestradiol and 2-methoxyoestradiol, two endogenous oestradiol metabolites, induce DNA fragmentation in Sertoli cells.Hypoxia-inducible factors: key regulators of myeloid cells during inflammation.GSNO promotes functional recovery in experimental TBI by stabilizing HIF-1α.Docking, synthesis, and in vitro evaluation of antimitotic estrone analogs.Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells.
P2860
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P2860
Mechanism of action of 2-methoxyestradiol: new developments.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Mechanism of action of 2-methoxyestradiol: new developments.
@ast
Mechanism of action of 2-methoxyestradiol: new developments.
@en
type
label
Mechanism of action of 2-methoxyestradiol: new developments.
@ast
Mechanism of action of 2-methoxyestradiol: new developments.
@en
prefLabel
Mechanism of action of 2-methoxyestradiol: new developments.
@ast
Mechanism of action of 2-methoxyestradiol: new developments.
@en
P1476
Mechanism of action of 2-methoxyestradiol: new developments.
@en
P2093
Susan L Mooberry
P304
P356
10.1016/J.DRUP.2003.10.001
P577
2003-12-01T00:00:00Z