Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds.
about
Protein C anticoagulant and cytoprotective pathwaysCytoprotective-selective activated protein C therapy for ischaemic strokeDifferential signaling by protease-activated receptors: implications for therapeutic targeting.Evaluation on potential contributions of protease activated receptors related mediators in allergic inflammation.Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteersEndothelial cell protein C receptor: a multiliganded and multifunctional receptorNoncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity.Activated protein C: biased for translation.β-Arrestin and dishevelled coordinate biased signaling.Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosisCharacterization of thrombin-bound dabigatran effects on protease-activated receptor-1 expression and signaling in vitro.G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation.N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling biasUbiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects.The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting.Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier StabilizationMechanisms of anticoagulant and cytoprotective actions of the protein C pathway.Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3.Protease-activated receptors in hemostasis.Cofactoring and dimerization of proteinase-activated receptorsProtease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by α-thrombin.Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impactDown-regulation of the clotting cascade by the protein C pathwayProtein C and acute inflammation: a clinical and biological perspective.Biased signaling of protease-activated receptors.2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).G Protein-Coupled Receptor Signaling Through β-Arrestin-Dependent Mechanisms.Targeting PAR1: Now What?Proximate Mediators of Microvascular Dysfunction at the Blood-Brain Barrier: Neuroinflammatory Pathways to NeurodegenerationOccupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin.Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases.Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C.Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4.PAR1 Biased Signaling is Required for Activated Protein C In Vivo Benefits in Sepsis and Stroke.The function of endocytosis in Wnt signaling.PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.Protease-Activated Receptor-1 Signaling: The Big Picture.
P2860
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P2860
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Activated protein C promotes p ...... n and dishevelled-2 scaffolds.
@ast
Activated protein C promotes p ...... n and dishevelled-2 scaffolds.
@en
type
label
Activated protein C promotes p ...... n and dishevelled-2 scaffolds.
@ast
Activated protein C promotes p ...... n and dishevelled-2 scaffolds.
@en
prefLabel
Activated protein C promotes p ...... n and dishevelled-2 scaffolds.
@ast
Activated protein C promotes p ...... n and dishevelled-2 scaffolds.
@en
P2860
P356
P1476
Activated protein C promotes p ...... n and dishevelled-2 scaffolds.
@en
P2093
JoAnn Trejo
Unice J K Soh
P2860
P304
P356
10.1073/PNAS.1112482108
P407
P577
2011-11-21T00:00:00Z