Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase
about
Functionally distinct double-stranded RNA-binding domains associated with alternative splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminaseAntiviral actions of interferonsHuman RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducibleImpact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionDeficient signaling in mice devoid of double-stranded RNA-dependent protein kinaseSensory denervation modulates eIF-2 alpha kinase expression in the rabbit lacrimal glandMechanism of interferon action: identification of essential positions within the novel 15-base-pair KCS element required for transcriptional activation of the RNA-dependent protein kinase pkr geneInvolvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activityTranslational control of viral gene expression in eukaryotesAntisense RNA: function and fate of duplex RNA in cells of higher eukaryotes.Tipping the balance: antagonism of PKR kinase and ADAR1 deaminase functions by virus gene products.Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicinRoles of vaccinia virus genes E3L and K3L and host genes PKR and RNase L during intratracheal infection of C57BL/6 mice.Potential role of PKR in double-stranded RNA-induced macrophage activation.West Nile virus infection does not induce PKR activation in rodent cells.Antiviral activity of limitin against encephalomyocarditis virus, herpes simplex virus, and mouse hepatitis virus: diverse requirements by limitin and alpha interferon for interferon regulatory factor 1.Mechanism of interferon action: characterization of the intermolecular autophosphorylation of PKR, the interferon-inducible, RNA-dependent protein kinase.Loss of protein kinase PKR expression in human HeLa cells complements the vaccinia virus E3L deletion mutant phenotype by restoration of viral protein synthesisMutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation.Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress ResponsesProtein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus.Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5'-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon.Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L.Prospective tests on biological models of acupuncture.ADARs: viruses and innate immunity.RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment.p48 (ISGF-3gamma) is involved in interferon-alpha-induced suppression of hepatitis B virus enhancer-1 activity.DNA damage-binding proteins and heterogeneous nuclear ribonucleoprotein A1 function as constitutive KCS element components of the interferon-inducible RNA-dependent protein kinase promoter.Up-Regulation of PKR Signaling Pathway by Ethanol Displays an Age of Onset-Dependent Relationship.Possible involvement of the double-stranded RNA-binding core protein sigmaA in the resistance of avian reovirus to interferon.Dual induction of PKR with E2F-1 and IFN-alpha to enhance gene therapy against hepatocellular carcinoma.A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR.IRF-1 reverts the transformed phenotype of oncogenically transformed cells in vitro and in vivo.Cooperative activity between HER oncogenes and the tumor suppressor IRF-1 results in apoptosis.Double-stranded RNA-dependent protein kinase mediates c-Myc suppression induced by type I interferons.The cell cycle control element of histone H4 gene transcription is maximally responsive to interferon regulatory factor pairs IRF-1/IRF-3 and IRF-1/IRF-7.Cell cycle regulation of histone H4 gene transcription requires the oncogenic factor IRF-2.Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR.Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR.Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.
P2860
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P2860
Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Mechanism of interferon action ...... e RNA-dependent protein kinase
@ast
Mechanism of interferon action ...... e RNA-dependent protein kinase
@en
type
label
Mechanism of interferon action ...... e RNA-dependent protein kinase
@ast
Mechanism of interferon action ...... e RNA-dependent protein kinase
@en
prefLabel
Mechanism of interferon action ...... e RNA-dependent protein kinase
@ast
Mechanism of interferon action ...... e RNA-dependent protein kinase
@en
P2860
P356
P1476
Mechanism of interferon action ...... e RNA-dependent protein kinase
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.17.7995
P407
P577
1994-08-01T00:00:00Z