Loss of protein kinase PKR expression in human HeLa cells complements the vaccinia virus E3L deletion mutant phenotype by restoration of viral protein synthesis
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Intracellular events and cell fate in filovirus infectionViral double-stranded RNAs from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-kappaB activation, when the K1 protein is absent or mutatedProtein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon responseHost-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 proteinActivation of the PI3K/Akt Pathway Early during Vaccinia and Cowpox Virus Infections Is Required for both Host Survival and Viral ReplicationRNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKRA survey of host range genes in poxvirus genomesPoxviruses and the evolution of host range and virulenceVaccinia virus E3 protein prevents the antiviral action of ISG15Mechanisms of protein kinase PKR-mediated amplification of beta interferon induction by C protein-deficient measles virusInduction of stress granules by interferon and down-regulation by the cellular RNA adenosine deaminase ADAR1.The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cellsRoles of vaccinia virus genes E3L and K3L and host genes PKR and RNase L during intratracheal infection of C57BL/6 mice.Adenosine deaminases acting on RNA, RNA editing, and interferon action.Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replicationHost response to polyomavirus infection is modulated by RNA adenosine deaminase ADAR1 but not by ADAR2Functional analysis of the short isoform of orf virus protein OV20.0.Comparative analysis of poxvirus orthologues of the vaccinia virus E3 protein: modulation of protein kinase R activity, cytokine responses, and virus pathogenicityMutational analysis of vaccinia virus E3 protein: the biological functions do not correlate with its biochemical capacity to bind double-stranded RNASpecies specificity of protein kinase r antagonism by cytomegalovirus TRS1 genesAdenosine deaminase acting on RNA 1 (ADAR1) suppresses the induction of interferon by measles virus.Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase.The amino terminus of the vaccinia virus E3 protein is necessary to inhibit the interferon responseStress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication.Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3.Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signalingProtein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus.Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activityBinding and relocalization of protein kinase R by murine cytomegalovirus.Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus MutantsProtein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L.Double-stranded RNA binding by the human cytomegalovirus PKR antagonist TRS1Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathways.Vaccinia virus K1L and C7L inhibit antiviral activities induced by type I interferons.Adenosine deaminase ADAR1 increases gene expression at the translational level by decreasing protein kinase PKR-dependent eIF-2alpha phosphorylation.ADARs: viruses and innate immunity.RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment.Variola virus E3L Zα domain, but not its Z-DNA binding activity, is required for PKR inhibitionEngineering oncolytic viruses to exploit tumor specific defects in innate immune signaling pathways.
P2860
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P2860
Loss of protein kinase PKR expression in human HeLa cells complements the vaccinia virus E3L deletion mutant phenotype by restoration of viral protein synthesis
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Loss of protein kinase PKR exp ...... ion of viral protein synthesis
@ast
Loss of protein kinase PKR exp ...... ion of viral protein synthesis
@en
type
label
Loss of protein kinase PKR exp ...... ion of viral protein synthesis
@ast
Loss of protein kinase PKR exp ...... ion of viral protein synthesis
@en
prefLabel
Loss of protein kinase PKR exp ...... ion of viral protein synthesis
@ast
Loss of protein kinase PKR exp ...... ion of viral protein synthesis
@en
P2093
P2860
P356
P1433
P1476
Loss of protein kinase PKR exp ...... ion of viral protein synthesis
@en
P2093
Bertram L Jacobs
Charles E Samuel
Ping Zhang
P2860
P304
P356
10.1128/JVI.01891-07
P407
P577
2007-10-24T00:00:00Z