Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci.
about
Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosisStructural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug actionA mitochondrial cytochrome b mutation causing severe respiratory chain enzyme deficiency in humans and yeastReconstructing the Qo site of Plasmodium falciparum bc 1 complex in the yeast enzymeStudies on inhibition of respiratory cytochrome bc1 complex by the fungicide pyrimorph suggest a novel inhibitory mechanismUnderstanding the mechanism of atovaquone drug resistance in Plasmodium falciparum cytochrome b mutation Y268S using computational methodsAssembly factors monitor sequential hemylation of cytochrome b to regulate mitochondrial translation.Ubiquinone synthesis in mitochondrial and microsomal subcellular fractions of Pneumocystis spp.: differential sensitivities to atovaquone.Human disease-related mutations in cytochrome b studied in yeast.Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiaeInhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapySaccharomyces cerevisiae-based mutational analysis of the bc1 complex Qo site residue 279 to study the trade-off between atovaquone resistance and function.HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.Mitochondrial heteroplasmy and the evolution of insecticide resistance: non-Mendelian inheritance in action.Structural basis of resistance to anti-cytochrome bc₁ complex inhibitors: implication for drug improvementIntroduction of cytochrome b mutations in Saccharomyces cerevisiae by a method that allows selection for both functional and non-functional cytochrome b proteins.Human Mitochondrial Cytochrome b Variants Studied in Yeast: Not All Are Silent Polymorphisms.Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits.Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance.Additive effect of nuclear and mitochondrial mutations in a patient with mitochondrial encephalomyopathy.A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.Combining Inhibitor Resistance-conferring Mutations in Cytochrome b Creates Conditional Synthetic Lethality in Saccharomyces cerevisiae.Molecular basis for atovaquone resistance in Pneumocystis jirovecii modeled in the cytochrome bc(1) complex of Saccharomyces cerevisiae.Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae.Characterization of the mechanism of action of the fungicide fenpicoxamid and its metabolite UK-2A.Targeting the mitochondrial respiratory chain of Cryptococcus through antifungal chemosensitization: a model for control of non-fermentative pathogens.Therapeutic efficacies of chitosan against Pneumocystis pneumonia of immunosuppressed rat.
P2860
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P2860
Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Recapitulation in Saccharomyce ...... uone in Pneumocystis jiroveci.
@ast
Recapitulation in Saccharomyce ...... uone in Pneumocystis jiroveci.
@en
type
label
Recapitulation in Saccharomyce ...... uone in Pneumocystis jiroveci.
@ast
Recapitulation in Saccharomyce ...... uone in Pneumocystis jiroveci.
@en
prefLabel
Recapitulation in Saccharomyce ...... uone in Pneumocystis jiroveci.
@ast
Recapitulation in Saccharomyce ...... uone in Pneumocystis jiroveci.
@en
P2093
P2860
P1476
Recapitulation in Saccharomyce ...... uone in Pneumocystis jiroveci.
@en
P2093
Bernard L Trumpower
Brigitte Meunier
Jacques Kessl
Nicholas Fisher
Philip Hill
Steven Meshnick
P2860
P304
P356
10.1128/AAC.47.9.2725-2731.2003
P407
P577
2003-09-01T00:00:00Z