Ribosome depurination is not sufficient for ricin-mediated cell death in Saccharomyces cerevisiae.
about
Toxin-based therapeutic approachesInhibition of the unfolded protein response by ricin a-chain enhances its cytotoxicity in mammalian cellsRicin A-chain requires c-Jun N-terminal kinase to induce apoptosis in nontransformed epithelial cells.Development of a quantitative RT-PCR assay to examine the kinetics of ribosome depurination by ribosome inactivating proteins using Saccharomyces cerevisiae as a model.Functional divergence between the two P1-P2 stalk dimers on the ribosome in their interaction with ricin A chainInteraction of ricin and Shiga toxins with ribosomesToxin instability and its role in toxin translocation from the endoplasmic reticulum to the cytosol.Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA.Identification of amino acids critical for the cytotoxicity of Shiga toxin 1 and 2 in Saccharomyces cerevisiae.Dislocation of ricin toxin A chains in human cells utilizes selective cellular factorsWild type RTA and less toxic variants have distinct requirements for Png1 for their depurination activity and toxicity in Saccharomyces cerevisiaeShiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2Ricinus communis intoxications in human and veterinary medicine-a summary of real cases.N-glycosylation does not affect the catalytic activity of ricin a chain but stimulates cytotoxicity by promoting its transport out of the endoplasmic reticulum.A relatively low level of ribosome depurination by mutant forms of ricin toxin A chain can trigger protein synthesis inhibition, cell signaling and apoptosis in mammalian cells.Targeting ricin to the ribosome.The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiaeArginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalkInduction of apoptosis by ribosome inactivating proteins: importance of N-glycosidase activity.Alpha-sarcin catalytic activity is not required for cytotoxicityRNA-Pt adducts following cisplatin treatment of Saccharomyces cerevisiae.Arabidopsis Bax Inhibitor-1 inhibits cell death induced by pokeweed antiviral protein in Saccharomyces cerevisiae.A Simple Fluorescence-based Reporter Assay to Identify Cellular Components Required for Ricin Toxin A Chain (RTA) Trafficking in Yeast.Cloning and Expression of Oil Palm (Elaeis guineensis Jacq.) Type 2 Ribosome Inactivating Protein in Escherichia coli
P2860
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P2860
Ribosome depurination is not sufficient for ricin-mediated cell death in Saccharomyces cerevisiae.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Ribosome depurination is not s ...... h in Saccharomyces cerevisiae.
@ast
Ribosome depurination is not s ...... h in Saccharomyces cerevisiae.
@en
type
label
Ribosome depurination is not s ...... h in Saccharomyces cerevisiae.
@ast
Ribosome depurination is not s ...... h in Saccharomyces cerevisiae.
@en
prefLabel
Ribosome depurination is not s ...... h in Saccharomyces cerevisiae.
@ast
Ribosome depurination is not s ...... h in Saccharomyces cerevisiae.
@en
P2093
P2860
P356
P1476
Ribosome depurination is not s ...... h in Saccharomyces cerevisiae.
@en
P2093
Hemalatha Saidasan
Marianne Baricevic
Nilgun E Tumer
Xiao-Ping Li
P2860
P304
P356
10.1128/IAI.01295-06
P407
P577
2006-11-13T00:00:00Z