Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.
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Mechanisms of altered Ca²⁺ handling in heart failureElevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasisA critical role for Telethonin in regulating t-tubule structure and function in the mammalian heartThe Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac AbnormalitiesWorld Health Organization Group I Pulmonary Hypertension: Epidemiology and Pathophysiology.Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure modelRole of phosphodiesterase-5 inhibitors in heart failure: emerging data and concepts.Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy.Recovery of the failing heart: emerging approaches and mechanisms in excitation-contraction couplingAutoTT: automated detection and analysis of T-tubule architecture in cardiomyocytesOverexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress.β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction.Dependence of cardiac transverse tubules on the BAR domain protein amphiphysin II (BIN-1)Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failureThe role of phosphodiesterase inhibitors in the management of pulmonary vascular diseasesIn situ single photon confocal imaging of cardiomyocyte T-tubule system from Langendorff-perfused heartsRight ventricular failure due to chronic pressure load: What have we learned in animal models since the NIH working group statement?Targeting cardiomyocyte Ca2+ homeostasis in heart failure.Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity.Spatial control of the βAR system in heart failure: the transverse tubule and beyond.Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure.Emerging mechanisms of T-tubule remodelling in heart failure.Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal developmentAlterations in ryanodine receptors and related proteins in heart failureSildenafil attenuates placental ischemia-induced hypertension.Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.Ca²⁺ microdomains organized by junctophilinsReversibility of T-tubule remodelling in heart failure: mechanical load as a dynamic regulator of the T-tubules.The transverse-axial tubular system of cardiomyocytes.The role of cGMP in the physiological and molecular responses of the right ventricle to pressure overload.Pharmacokinetic evaluation of sildenafil as a pulmonary hypertension treatment.Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases.Adaptive capacity of the right ventricle: why does it fail?Manipulation of sarcoplasmic reticulum Ca(2+) release in heart failure through mechanical intervention.Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats.MicroRNA: a toolkit fine-tuning the dyadic "fuzzy space"?Long-acting PDE5 inhibitor tadalafil prevents early doxorubicin-induced left ventricle diastolic dysfunction in juvenile mice: potential role of cytoskeletal proteins.Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension.Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca2+]i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity.
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Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Sildenafil prevents and revers ...... pulmonary artery hypertension.
@ast
Sildenafil prevents and revers ...... pulmonary artery hypertension.
@en
type
label
Sildenafil prevents and revers ...... pulmonary artery hypertension.
@ast
Sildenafil prevents and revers ...... pulmonary artery hypertension.
@en
prefLabel
Sildenafil prevents and revers ...... pulmonary artery hypertension.
@ast
Sildenafil prevents and revers ...... pulmonary artery hypertension.
@en
P2093
P2860
P50
P1433
P1476
Sildenafil prevents and revers ...... pulmonary artery hypertension
@en
P2093
Kathy Zimmerman
Lie-Cheng Wang
Mark E Anderson
Philip Sanders
Robert M Weiss
Yu-Ping Xie
P2860
P304
P356
10.1161/HYPERTENSIONAHA.111.180968
P407
P577
2011-12-27T00:00:00Z