Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development
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Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure modelRegulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy.AutoTT: automated detection and analysis of T-tubule architecture in cardiomyocytesCa(2+) homeostasis in sealed t-tubules of mouse ventricular myocytes.Dependence of cardiac transverse tubules on the BAR domain protein amphiphysin II (BIN-1)In situ single photon confocal imaging of cardiomyocyte T-tubule system from Langendorff-perfused heartsMolecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes.Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice.Ca²⁺ microdomains organized by junctophilinsCa handling during excitation-contraction coupling in heart failure.Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases.Calcium signalling in developing cardiomyocytes: implications for model systems and disease.MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress.Chronic heart failure: Ca(2+), catabolism, and catastrophic cell death.Early transverse tubule development begins in utero in the sheep heart.Cardiac BIN1 (cBIN1) is a regulator of cardiac contractile function and an emerging biomarker of heart muscle health.Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo.Altered Na/Ca exchange distribution in ventricular myocytes from failing hearts.Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts.Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure.The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway.Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes.CASAAV Technology to Examine Regulators of Heart Failure: Cause or Effect.Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues.Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca2+]i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity.Highly variable contractile performance correlates with myocyte content in trabeculae from failing human hearts.Variable t-tubule organization and Ca2+ homeostasis across the atria.Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling MicrodomainsUnraveling the Mechanisms by Which Calpain Inhibition Prevents Heart Failure DevelopmentTargeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models
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Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Critical roles of junctophilin ...... n during postnatal development
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Critical roles of junctophilin ...... during postnatal development.
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type
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Critical roles of junctophilin ...... n during postnatal development
@en
Critical roles of junctophilin ...... during postnatal development.
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prefLabel
Critical roles of junctophilin ...... n during postnatal development
@en
Critical roles of junctophilin ...... during postnatal development.
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P2093
P2860
P356
P1476
Critical roles of junctophilin ...... n during postnatal development
@en
P2093
Caimei Zhang
Jiang Hong
Kathy Zimmerman
Leonid Zingman
Long-Sheng Song
Mark E Anderson
Robert M Weiss
P2860
P356
10.1093/CVR/CVT180
P577
2013-07-16T00:00:00Z