Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. - Wikidata - awgldk - TriplyDB

Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.

Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.

http://www.wikidata.org/entity/Q35709954

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Research Advances on Pathways of Nickel-Induced Apoptosis Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches Nickel chloride (NiCl2) in hepatic toxicity: apoptosis, G2/M cell cycle arrest and inflammatory response Mechanisms for insulin resistance: common threads and missing links The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP.Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.The Role of INDY in Metabolic Regulation The transcription factor XBP1 is selectively required for eosinophil differentiation.Inflammation, metaflammation and immunometabolic disorders.Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II.Refeeding-induced brown adipose tissue glycogen hyper-accumulation in mice is mediated by insulin and catecholamines Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance.Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity.Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease?The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.Effect of Cudrania tricuspidata and Kaempferol in Endoplasmic Reticulum Stress-Induced Inflammation and Hepatic Insulin Resistance in HepG2 Cells.Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways.Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance.Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes.Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue.Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress.Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle.The role of lipids in the pathogenesis and treatment of type 2 diabetes and associated co-morbidities.Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.Inflammation during obesity is not all bad: evidence from animal and human studies.Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes.Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion The role of the unfolded protein response in diabetes mellitus.

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Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.

http://www.wikidata.org/entity/Q35709954

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Dissociation of inositol-requi ...... otein-1 (XBP1) knock-out mice.

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Dissociation of inositol-requi ...... otein-1 (XBP1) knock-out mice.

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Dissociation of inositol-requi ...... otein-1 (XBP1) knock-out mice.

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Dissociation of inositol-requi ...... otein-1 (XBP1) knock-out mice.

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Dissociation of inositol-requi ...... otein-1 (XBP1) knock-out mice.

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JBC.M111.316760

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Journal of Biological Chemistry

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Dissociation of inositol-requi ...... otein-1 (XBP1) knock-out mice.

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Andreas L Birkenfeld

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Ann-Hwee Lee

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Blas A Guigni

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Francois R Jornayvaz

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Hui-Young Lee

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Laurie H Glimcher

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Mario Kahn

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Michael J Jurczak

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Varman T Samuel

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P2860

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4

Regulation of hepatic lipogenesis by the transcription factor XBP1

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

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2558-2567

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10.1074/JBC.M111.316760

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4

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287

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Gerald I. Shulman

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2011-11-28T00:00:00Z

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22128176

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