Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
about
BRCAness: finding the Achilles heel in ovarian cancerHow the fanconi anemia pathway guards the genomeThe combined status of ATM and p53 link tumor development with therapeutic responseTrial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyHomologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian CancerExploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer TherapyFanconi anemia and the cell cycle: new perspectives on aneuploidyTargeting DNA damage response in cancer therapyCellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insightsOuabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agentsPrinciples of cancer therapy: oncogene and non-oncogene addictionThe role of the Fanconi anemia network in the response to DNA replication stress.The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia.Mechanisms of a novel anticancer therapeutic strategy involving atmospheric pressure plasma-mediated apoptosis and DNA strand break formation.Human synthetic lethal inference as potential anti-cancer target gene detectionDiscovery of DNA repair inhibitors by combinatorial library profiling.Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signalingMycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate.Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.BRCAness profile of sporadic ovarian cancer predicts disease recurrence.Characterization of DDRI-18 (3,3'-(1H,3'H-5,5'-bibenzo[d]imidazole-2,2'-diyl)dianiline), a novel small molecule inhibitor modulating the DNA damage response.Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin.Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.ATM signalling and cancer.Loss of ATM kinase activity leads to embryonic lethality in miceInhibition of DNA glycosylases via small molecule purine analogsTargeting abnormal DNA double strand break repair in cancerThe Fanconi anemia pathway and ICL repair: implications for cancer therapy.Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma.Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition.A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapyDNA helicases involved in DNA repair and their roles in cancerKinase-dead ATM protein causes genomic instability and early embryonic lethality in miceFANCA safeguards interphase and mitosis during hematopoiesis in vivo.Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaksTorin2 Suppresses Ionizing Radiation-Induced DNA Damage RepairWerner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumorsDNA damage tolerance: a double-edged sword guarding the genomeCoordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway.
P2860
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P2860
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Fanconi anemia pathway-deficie ...... ataxia telangiectasia mutated.
@ast
Fanconi anemia pathway-deficie ...... ataxia telangiectasia mutated.
@en
type
label
Fanconi anemia pathway-deficie ...... ataxia telangiectasia mutated.
@ast
Fanconi anemia pathway-deficie ...... ataxia telangiectasia mutated.
@en
prefLabel
Fanconi anemia pathway-deficie ...... ataxia telangiectasia mutated.
@ast
Fanconi anemia pathway-deficie ...... ataxia telangiectasia mutated.
@en
P2093
P2860
P356
P1476
Fanconi anemia pathway-deficie ...... ataxia telangiectasia mutated.
@en
P2093
Akiko Shimamura
Alan D D'Andrea
Clark C Chen
Elyse M Archila
Lisa A Moreau
Michelle A De la Vega
Patricia Stuckert
Richard D Kennedy
P2860
P304
P356
10.1172/JCI31245
P407
P577
2007-04-12T00:00:00Z