A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. - Wikidata - awgldk - TriplyDB

A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.

A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.

http://www.wikidata.org/entity/Q35742838

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O-GlcNAcylation and Metabolic Reprograming in Cancer Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination.The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas.Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC.Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes An anti-cancer Smurf.Role of the Exocyst Complex Component Sec6/8 in Genomic Stability Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma.Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways.Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41.Ubiquitination of tumor necrosis factor receptor-associated factor 4 (TRAF4) by Smad ubiquitination regulatory factor 1 (Smurf1) regulates motility of breast epithelial and cancer cells Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1.Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.Inhibition of Smurf2 translation by miR-322/503 modulates TGF-β/Smad2 signaling and intestinal epithelial homeostasis.The enigmatic role of H2Bub1 in cancer.A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.An unconventional role of BMP-Smad1 signaling in DNA damage response: a mechanism for tumor suppression.Prediction of novel genes associated with negative regulators of toll-like receptors-induced inflammation based on endotoxin tolerance.Diverse Functions and Signal Transduction of the Exocyst Complex in Tumor Cells.Posttranscriptional regulation of intestinal epithelial integrity by noncoding RNAs.Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate.A regularized multivariate regression approach for eQTL analysis.The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods.Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.Challenges for Super-Resolution Localization Microscopy and Biomolecular Fluorescent Nano-Probing in Cancer Research.Protein Arginine Methyltransferase 1 Methylates Smurf2.Ubiquitylation at the crossroads of development and disease.Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ.The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery.E3 ubiquitin ligases in cancer and implications for therapies.

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A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.

http://www.wikidata.org/entity/Q35742838

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A tumor suppressor function of ...... enome stability through RNF20.

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A tumor suppressor function of ...... enome stability through RNF20.

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Michael Blank

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Motozo Yamashita

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Sandra S Burkett

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Steven Y Cheng

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Yi Tang

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Ying E Zhang

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P2860

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions

An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein

Regulation of planar cell polarity by Smurf ubiquitin ligases

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells

Smurf2 up-regulation activates telomere-dependent senescence

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