PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress. - Wikidata - awgldk - TriplyDB

PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress.

PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress.

http://www.wikidata.org/entity/Q35744022

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Pharmacological Modulators of Endoplasmic Reticulum Stress in Metabolic Diseases Islet inflammation: a unifying target for diabetes treatment?Lost in translation: endoplasmic reticulum stress and the decline of β-cell health in diabetes mellitus Translational implications of the β-cell epigenome in diabetes mellitus CDK5-induced p-PPARγ(Ser 112) downregulates GFAP via PPREs in developing rat brain: effect of metal mixture and troglitazone in astrocytes.Human adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: analysis of hASC-derived paracrine effectors.Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death.Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell.PPARγ activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability.Cdk5 inhibitory peptide (CIP) inhibits Cdk5/p25 activity induced by high glucose in pancreatic beta cells and recovers insulin secretion from p25 damage.Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection.SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell PPARγ Ligands Regulate Noncontractile and Contractile Functions of Airway Smooth Muscle: Implications for Asthma Therapy.Nitric oxide stress and activation of AMP-activated protein kinase impair β-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability Cdk5r1 Overexpression Induces Primary β-Cell Proliferation.Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ.Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells Update on the protective molecular pathways improving pancreatic beta-cell dysfunction IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.Peroxisome proliferator-activated receptor γ (PPARγ) and its target genes are downstream effectors of FoxO1 protein in islet β-cells: mechanism of β-cell compensation and failure.Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco/Endoplasmic Reticulum Ca2+-ATPase 2 Expression in Diabetic Nephropathy.Calcium efflux from the endoplasmic reticulum leads to β-cell death.New insights into the role of connexins in pancreatic islet function and diabetes.Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.Impairment of calcium ATPases by high glucose and potential pharmacological protection.Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice Endoplasmic reticulum stress in beta cells and autoimmune diabetes.SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity.Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy.TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis.Autocrine activation of P2Y1 receptors couples Ca (2+) influx to Ca (2+) release in human pancreatic beta cells.SERCA control of cell death and survival.Skeletal muscle dysfunction in the db/db mouse model of type 2 diabetes.The Common and Distinct Features of Brown and Beige Adipocytes.Endoplasmic Reticulum Stress and Obesity.MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells.Pioglitazone Attenuates Palmitate-Induced Inflammation and Endoplasmic Reticulum Stress in Pancreatic β-Cells.Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β cell survival.

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PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress.

http://www.wikidata.org/entity/Q35744022

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

@zh-tw

2012年论文

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2012年论文

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2012年论文

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name

PPAR-γ activation restores pan ...... rglycemic and cytokine stress.

@ast

PPAR-γ activation restores pan ...... rglycemic and cytokine stress.

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type

label

PPAR-γ activation restores pan ...... rglycemic and cytokine stress.

@ast

PPAR-γ activation restores pan ...... rglycemic and cytokine stress.

@en

prefLabel

PPAR-γ activation restores pan ...... rglycemic and cytokine stress.

@ast

PPAR-γ activation restores pan ...... rglycemic and cytokine stress.

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Molecular Endocrinology

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PPAR-γ activation restores pan ...... rglycemic and cytokine stress.

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Angel Zarain-Herzberg

http://www.w3.org/2001/XMLSchema#string

Dan R Moss

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Geonyoung Ahn

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Liann Gann

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Patrick T Fueger

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Takeshi Ogihara

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Tatsuyoshi Kono

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Yurika Nishiki

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P2860

Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor

Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion.

Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin

Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis

Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding.

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257-271

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10.1210/ME.2011-1181

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2

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26

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Carmella Evans-Molina

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2012-01-12T00:00:00Z

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221743575

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22240811

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3275161

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