Calcium efflux from the endoplasmic reticulum leads to β-cell death. - Wikidata - awgldk - TriplyDB

Calcium efflux from the endoplasmic reticulum leads to β-cell death.

Calcium efflux from the endoplasmic reticulum leads to β-cell death.

http://www.wikidata.org/entity/Q37594059

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Wolfram Syndrome: Diagnosis, Management, and Treatment Calcium release channel RyR2 regulates insulin release and glucose homeostasis A novel CISD2 mutation associated with a classical Wolfram syndrome phenotype alters Ca2+ homeostasis and ER-mitochondria interactions.Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death.A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome Research resource: Monitoring endoplasmic reticulum membrane integrity in β-cells at the single-cell level.Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids.Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the Translocon Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.Nitric oxide stress and activation of AMP-activated protein kinase impair β-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function T-Type voltage-sensitive calcium channels mediate mechanically-induced intracellular calcium oscillations in osteocytes by regulating endoplasmic reticulum calcium dynamics.IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes.A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response.Sarco(endo)plasmic reticulum ATPase is a molecular partner of Wolfram syndrome 1 protein, which negatively regulates its expression.Endoplasmic reticulum stress in beta cells and autoimmune diabetes.Sodium fluorocitrate having protective effect on palmitate-induced beta cell death improves hyperglycemia in diabetic db/db mice Association between corneal endothelial cell densities and elevated cytokine levels in the aqueous humor.SERCA control of cell death and survival.A novel heterozygous mutation of the WFS1 gene leading to constitutive endoplasmic reticulum stress is the cause of Wolfram syndrome.Endoplasmic Reticulum Stress and Obesity.Wolfram syndrome: MAMs' connection?MCU-knockdown attenuates high glucose-induced inflammation through regulating MAPKs/NF-κB pathways and ROS production in HepG2 cells.IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases.Wolfram Syndrome: A Case Report and Review of Clinical Manifestations, Genetics Pathophysiology, and Potential Therapies.

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Calcium efflux from the endoplasmic reticulum leads to β-cell death.

http://www.wikidata.org/entity/Q37594059

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on January 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Calcium efflux from the endoplasmic reticulum leads to β-cell death.

@en

Calcium efflux from the endoplasmic reticulum leads to β-cell death.

@nl

type

label

Calcium efflux from the endoplasmic reticulum leads to β-cell death.

@en

Calcium efflux from the endoplasmic reticulum leads to β-cell death.

@nl

prefLabel

Calcium efflux from the endoplasmic reticulum leads to β-cell death.

@en

Calcium efflux from the endoplasmic reticulum leads to β-cell death.

@nl

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Calcium efflux from the endoplasmic reticulum leads to β-cell death.

@en

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Fumihiko Urano

http://www.w3.org/2001/XMLSchema#string

Jana Mahadevan

http://www.w3.org/2001/XMLSchema#string

Kohsuke Kanekura

http://www.w3.org/2001/XMLSchema#string

Mariko Hara

http://www.w3.org/2001/XMLSchema#string

Simin Lu

http://www.w3.org/2001/XMLSchema#string

Takashi Hara

http://www.w3.org/2001/XMLSchema#string

P2860

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

Endoplasmic reticulum stress: cell life and death decisions.

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion

The versatility and universality of calcium signalling

Calcium signalling: dynamics, homeostasis and remodelling

Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model.

Measuring calcium signaling using genetically targetable fluorescent indicators.

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758-768

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scholarly article

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10.1210/EN.2013-1519

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3

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155

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2013-01-01T00:00:00Z

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259724010

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24424032

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endoplasmic reticulum

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3929724

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