AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells.
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Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activationMutations of PIK3CA in gastric adenocarcinomaMulti-walled carbon nanotube-induced gene expression in the mouse lung: association with lung pathologyRegulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathwayAkt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 functionCaspase-3-mediated cleavage of Akt: involvement of non-consensus sites and influence of phosphorylationShepherding AKT and androgen receptor by Ack1 tyrosine kinaseAkt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expressionMOZ increases p53 acetylation and premature senescence through its complex formation with PMLAkt and autophagy cooperate to promote survival of drug-resistant gliomaAkt2: a role in breast cancer metastasisCelecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours"Ziziphus jujuba": A red fruit with promising anticancer activitiesThe PI3K/AKT Pathway and Renal Cell CarcinomaDownregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4A transforming mutation in the pleckstrin homology domain of AKT1 in cancerHonokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivoPhosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberinArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survivalPI3K-independent AKT activation in cancers: a treasure trove for novel therapeuticsNitrosylcobalamin potentiates the anti-neoplastic effects of chemotherapeutic agents via suppression of survival signalingModulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screeningCancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domainIdentification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro.Computational identification of significant missense mutations in AKT1 gene.Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma.Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalitiesActivation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic miceAkt2 inhibition enables the forkhead transcription factor FoxO3a to have a repressive role in estrogen receptor alpha transcriptional activity in breast cancer cells.The multiple facets of drug resistance: one history, different approaches.A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.Is homologous recombination really an error-free process?A chemical epitope-targeting strategy for protein capture agents: the serine 474 epitope of the kinase Akt2.Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells.Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomasInhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency.Antitumor activity of a novel antisense oligonucleotide against Akt1.AKT plays a central role in tumorigenesis.FOXO1A is a target for HER2-overexpressing breast tumors.
P2860
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P2860
AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
AKT1/PKBalpha kinase is freque ...... ransformation in NIH3T3 cells.
@ast
AKT1/PKBalpha kinase is freque ...... ransformation in NIH3T3 cells.
@en
type
label
AKT1/PKBalpha kinase is freque ...... ransformation in NIH3T3 cells.
@ast
AKT1/PKBalpha kinase is freque ...... ransformation in NIH3T3 cells.
@en
prefLabel
AKT1/PKBalpha kinase is freque ...... ransformation in NIH3T3 cells.
@ast
AKT1/PKBalpha kinase is freque ...... ransformation in NIH3T3 cells.
@en
P2093
P2860
P1476
AKT1/PKBalpha kinase is freque ...... ransformation in NIH3T3 cells.
@en
P2093
J E Paciga
P N Tsichlis
R I Feldman
S A Shelley
S V Nicosia
P2860
P304
P356
10.1016/S0002-9440(10)61714-2
P407
P577
2001-08-01T00:00:00Z