Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway. - Wikidata - awgldk - TriplyDB

Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.

Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.

http://www.wikidata.org/entity/Q35750835

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Temporal changes in rat liver gene expression after acute cadmium and chromium exposure CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A.From Genome to Structure and Back Again: A Family Portrait of the Transcarbamylases Dihydroorotase from the Hyperthermophile Aquifiex aeolicus Is Activated by Stoichiometric Association with Aspartate Transcarbamoylase and Forms a One-Pot Reactor for Pyrimidine Biosynthesis † ‡The Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled Oligomerization The mononuclear metal center of type-I dihydroorotase from aquifex aeolicus Structure of the catalytic chain ofMethanococcus jannaschiiaspartate transcarbamoylase in a hexagonal crystal form: insights into the path of carbamoyl phosphate to the active site of the enzyme Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules Sending Out an SOS: Mitochondria as a Signaling Hub Microsporidia: Why Make Nucleotides if You Can Steal Them?Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines Leflunomide reduces proliferation and induces apoptosis in neuroblastoma cells in vitro and in vivo Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine Chronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in Mice Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth.Francisella tularensis DeltapyrF mutants show that replication in nonmacrophages is sufficient for pathogenesis in vivo.Teriflunomide (leflunomide) promotes cytostatic, antioxidant, and apoptotic effects in transformed prostate epithelial cells: evidence supporting a role for teriflunomide in prostate cancer chemoprevention.Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway.Targeting mTORC1-mediated metabolic addiction overcomes fludarabine resistance in malignant B cells.Phosphorylation of CTP synthetase from Saccharomyces cerevisiae by protein kinase C Immunology: When lymphocytes run out of steam.Co-enzyme Q10 and idebenone use in Friedreich's ataxia.Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis.Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)NMR-based stable isotope resolved metabolomics in systems biochemistry.Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency.Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase).Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.Expression, purification, crystallization and preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD.

P2860

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P2860

Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.

http://www.wikidata.org/entity/Q35750835

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2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.

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Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.

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Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.

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Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.

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Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.

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Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.

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Journal of Biological Chemistry

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Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.

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David R Evans

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Hedeel I Guy

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P2860

Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis

Molecular cloning and nucleotide sequence for the complete coding region of human UMP synthase

Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center

Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase

Leflunomide for the treatment of rheumatoid arthritis and autoimmunity

Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product

Required allosteric effector site for N-acetylglutamate on carbamoyl-phosphate synthetase I

Regulation of carbamoyl phosphate synthetase by MAP kinase

Oligomeric structure of the multifunctional protein CAD that initiates pyrimidine biosynthesis in mammalian cells

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33035-33038

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scholarly article

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10.1074/JBC.R400007200

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32

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279

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15096496

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