Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells
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mTOR signaling in growth control and diseaseMilk--A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent TranslationRole of AKT/mTORC1 pathway in pancreatic β-cell proliferationNatural history of β-cell adaptation and failure in type 2 diabetesPhosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-CellsIslet biology, the CDKN2A/B locus and type 2 diabetes risk.Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese.Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Increasing β-cell mass requires additional stimulation for adaptation to secretory demandChronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartumInhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell deathFree fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2).mTORC1 signaling and regulation of pancreatic β-cell mass.S6K1 controls pancreatic β cell size independently of intrauterine growth restrictionFractalkine signaling in regulation of insulin secretion.Human β-cell proliferation and intracellular signaling: driving in the dark without a road map.Answering the ultimate question "what is the proximal cause of aging?"Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes.Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin ReceptorThe role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes.A molecular rheostat at the interface of cancer and diabetesEvidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass.Advances in β cell replacement and regeneration strategies for treating diabetesMammalian target of rapamycin (mTOR) as a potential therapeutic target in various diseases.Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass.
P2860
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P2860
Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Decreased IRS signaling impair ...... erexpressing S6K in beta-cells
@ast
Decreased IRS signaling impair ...... erexpressing S6K in beta-cells
@en
type
label
Decreased IRS signaling impair ...... erexpressing S6K in beta-cells
@ast
Decreased IRS signaling impair ...... erexpressing S6K in beta-cells
@en
prefLabel
Decreased IRS signaling impair ...... erexpressing S6K in beta-cells
@ast
Decreased IRS signaling impair ...... erexpressing S6K in beta-cells
@en
P2093
P2860
P356
P1433
P1476
Decreased IRS signaling impair ...... erexpressing S6K in beta-cells
@en
P2093
Aaron P Gould
Ernesto Bernal-Mizrachi
Kelle H Moley
Maggie M Chi
Manuel Blandino-Rosano
Norman Balcazar
Szabolcs Fatrai
P2860
P304
P356
10.2337/DB09-0851
P407
P577
2010-07-09T00:00:00Z