Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18
about
Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?Type 2 diabetes: etiology and reversibilityIslet biology, the CDKN2A/B locus and type 2 diabetes risk.Pancreatic β-cell proliferation in obesity.The negative cell cycle regulators, p27(Kip1), p18(Ink4c), and GSK-3, play critical role in maintaining quiescence of adult human pancreatic β-cells and restrict their ability to proliferate.Human β-cell regeneration: progress, hurdles, and controversy.Age-related impairment of pancreatic Beta-cell function: pathophysiological and cellular mechanisms.Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathwayDoes inhibition of β-cell proliferation by free fatty acid in mice explain the progressive failure of insulin secretion in type 2 diabetes?Insulin demand regulates β cell number via the unfolded protein response.Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism.The role of aging upon β cell turnover.Upregulation of p21 activates the intrinsic apoptotic pathway in β-cellsAdaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.Genetic modifiers of cystic fibrosis-related diabetesCISH has no non-redundant functions in glucose homeostasis or beta cell proliferation during pregnancy in mice.The Heart and Medicine: Exploring the Interconnectedness of Cardiometabolic-related Concerns Through a Systems Biology ApproachA model of chronic nutrient infusion in the rat.Mild hyperglycemia triggered islet function recovery in streptozotocin-induced insulin-deficient diabetic rats.Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1.Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin ReceptorNutrient regulation of pancreatic β-cell proliferation.Saturated free fatty acids: islet β cell "stressERs".Banting Memorial lecture 2012: reversing the twin cycles of type 2 diabetes.CDKN2A/B T2D GWAS Risk-SNPs Impact Locus Gene Expression and Proliferation in Human Islets.Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats.Effect of cocoa in diabetes: the potential of the pancreas and liver as key target organs, more than an antioxidant effect?
P2860
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P2860
Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Free fatty acids block glucose ...... l cycle inhibitors p16 and p18
@ast
Free fatty acids block glucose ...... l cycle inhibitors p16 and p18
@en
type
label
Free fatty acids block glucose ...... l cycle inhibitors p16 and p18
@ast
Free fatty acids block glucose ...... l cycle inhibitors p16 and p18
@en
prefLabel
Free fatty acids block glucose ...... l cycle inhibitors p16 and p18
@ast
Free fatty acids block glucose ...... l cycle inhibitors p16 and p18
@en
P2093
P2860
P356
P1433
P1476
Free fatty acids block glucose ...... l cycle inhibitors p16 and p18
@en
P2093
Adolfo Garcia-Ocana
Christopher P O'Donnell
Douglas Hollern
Jordan Pascoe
Laura C Alonso
Lia C Romano
Munira Abbasi
Rachel Stamateris
P2860
P304
P356
10.2337/DB11-0991
P407
P577
2012-02-14T00:00:00Z