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Synthesis of nucleoside phosphate and phosphonate prodrugsHistidine triad nucleotide-binding protein 1 (HINT-1) phosphoramidase transforms nucleoside 5'-O-phosphorothioates to nucleoside 5'-O-phosphatesHydrolytic reactions of thymidine 5'-o-phenyl-N-alkylphosphoramidates, models of nucleoside 5'-monophosphate prodrugs.A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds.INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides.Thiophene-expanded guanosine analogues of Gemcitabine.A multifunctional catalyst that stereoselectively assembles prodrugs.Improving nucleoside analogs via lipid conjugation: Is fatter any better?Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines.Synthesis of nucleoside mono-, di-, and triphosphoramidates from solid-phase cyclosaligenyl phosphitylating reagentsEvolution of an amino acid based prodrug approach: stay tuned.The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition.Nucleotide analogue prodrug tenofovir disoproxil enhances lymphoid cell loading following oral administration in monkeys.Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells.Novel developments in the use of antimetabolites.Flex-nucleoside analogues - Novel therapeutics against filoviruses.ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolitesMembrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.Synthesis of novel 2',3'-didehydro-2',3'-dideoxyinosine phosphoramidate prodrugs and evaluation of their anticancer activity.2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.Synthesis, Hydrolysis, and Protonation-Promoted Intramolecular Reductive Breakdown of Potential NRTIs: Stavudine α-P-Borano-γ-P-N-l-tryptophanyltriphosphates.Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity.Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antiviralsAspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication.Enhanced inhibition of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosineAdenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses.Synthesis and anti-herpetic activity of phosphoramidate ProTides.Chemical and enzymatic stability of amino acid derived phosphoramidates of antiviral nucleoside 5'-monophosphates bearing a biodegradable protecting group.Decomposition of 3'-azido-2',3'-dideoxythymidine 5'-monophosphate (AZTMP) prodrugs in biological media studied by on-line solid-phase extraction coupled to liquid chromatography mass spectrometry.Negative ion electrospray ionization mass spectrometry of nucleoside phosphoramidate monoesters: elucidation of novel rearrangement mechanisms by multistage mass spectrometry incorporating in-source deuterium labelling.Nucleoside diphosphate and triphosphate prodrugs - An unsolvable task?Fluorinated nucleosides as an important class of anticancer and antiviral agents.Influence of the nucleobase and anchimeric assistance of the carboxyl acid groups in the hydrolysis of amino acid nucleoside phosphoramidates.AZT and AZT-monophosphate prodrugs incorporating HIV-protease substrate fragment: synthesis and evaluation as specific drug delivery systems.DBN hexafluorophosphate salts as convenient sulfonylating and phosphonylating agents.Cyclic-disulfide-based prodrugs for cytosol-specific drug delivery.Development and validation of a phenotypic high-content imaging assay for assessing the antiviral activity of small-molecule inhibitors targeting the Zika virus
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Aryloxy phosphoramidate triesters as pro-tides.
@ast
Aryloxy phosphoramidate triesters as pro-tides.
@en
type
label
Aryloxy phosphoramidate triesters as pro-tides.
@ast
Aryloxy phosphoramidate triesters as pro-tides.
@en
prefLabel
Aryloxy phosphoramidate triesters as pro-tides.
@ast
Aryloxy phosphoramidate triesters as pro-tides.
@en
P356
P1476
Aryloxy phosphoramidate triesters as pro-tides.
@en
P2093
Christopher McGuigan
Dominique Cahard
P304
P356
10.2174/1389557043403936
P577
2004-05-01T00:00:00Z