The role of Cdx proteins in intestinal development and cancer.
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Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targetsMultilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers.Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagusVariations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2 French Canadian families with high risk of breast cancerIkappaBalpha polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese.Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagusBile acids initiate lineage-addicted gastroesophageal tumorigenesis by suppressing the EGF receptor-AKT axis.The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex.Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancerEnforcement of developmental lineage specificity by transcription factor Oct1.Ectopic Cdx2 expression in murine esophagus models an intermediate stage in the emergence of Barrett's esophagus.Right-side and left-side colon cancer follow different pathways to relapseAcid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus.TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regionsModeling human gastrointestinal inflammatory diseases using microphysiological culture systems.Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development.Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis.Caudal genes in blood development and leukemia.Defining new criteria for selection of cell-based intestinal models using publicly available databases.Cdx1 and Cdx2 exhibit transcriptional specificity in the intestine.Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membraneDifferentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states.Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients.Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells.Efficient derivation of pluripotent stem cells from siRNA-mediated Cdx2-deficient mouse embryos.Essential and redundant functions of caudal family proteins in activating adult intestinal genesCox2 and β-catenin/T-cell factor signaling intestinalize human esophageal keratinocytes when cultured under organotypic conditionsKrüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestineEpCAM and gpA33 are markers of Barrett's metaplasiaN-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression.HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation.Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition.Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagusFoxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasisGlucagonlike peptide 2 analogue teduglutide: stimulation of proliferation but reduction of differentiation in human Caco-2 intestinal epithelial cellsInhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4.The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine.CDX2 is an amplified lineage-survival oncogene in colorectal cancer.
P2860
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P2860
The role of Cdx proteins in intestinal development and cancer.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The role of Cdx proteins in intestinal development and cancer.
@ast
The role of Cdx proteins in intestinal development and cancer.
@en
type
label
The role of Cdx proteins in intestinal development and cancer.
@ast
The role of Cdx proteins in intestinal development and cancer.
@en
prefLabel
The role of Cdx proteins in intestinal development and cancer.
@ast
The role of Cdx proteins in intestinal development and cancer.
@en
P2093
P356
P1476
The role of Cdx proteins in intestinal development and cancer.
@en
P2093
Eun Ran Suh
John P Lynch
Rong-Jun Guo
P304
P356
10.4161/CBT.3.7.913
P577
2004-07-09T00:00:00Z