Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons - Wikidata - awgldk - TriplyDB

Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons

Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons

http://www.wikidata.org/entity/Q35784689

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SLE-associated risk factors affect DC function Interferon-regulatory factors determine macrophage phenotype polarization RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE.IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis C1q-mediated repression of human monocytes is regulated by leukocyte-associated Ig-like receptor 1 (LAIR-1).Mangiferin inhibits macrophage classical activation via downregulating interferon regulatory factor 5 expression.Monocytes from Irf5-/- mice have an intrinsic defect in their response to pristane-induced lupus.Genetics of SLE: functional relevance for monocytes/macrophages in disease RETRACTED: The COP9 signalosome interacts with and regulates interferon regulatory factor 5 protein stability.Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response.Imaging Immunosenescence.Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality.IRF5 is a specific marker of inflammatory macrophages in vivo.DNA-reactive B cells in lupus.Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics.RNAi Screen and Proteomics Reveal NXF1 as a Novel Regulator of IRF5 Signaling.Mass cytometry identifies a distinct monocyte cytokine signature shared by clinically heterogeneous pediatric SLE patients.IRF5 is elevated in childhood-onset SLE and regulated by histone acetyltransferase and histone deacetylase inhibitors.IRF5, IRF8, and IRF7 in human pDCs - the good, the bad, and the insignificant?B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation.Corrected and Republished from: The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability.High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus.

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Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons

http://www.wikidata.org/entity/Q35784689

description

2012 nî lūn-bûn

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Interferon regulatory factor 5 ...... ependent of type I interferons

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Interferon regulatory factor 5 ...... ependent of type I interferons

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Interferon regulatory factor 5 ...... ependent of type I interferons

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Interferon regulatory factor 5 ...... ependent of type I interferons

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Arthritis & Rheumatology

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Interferon regulatory factor 5 ...... ependent of type I interferons

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Betsy J Barnes

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Di Feng

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Jing Deng

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Lars Rönnblom

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Lisong Yang

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Maija-Leena Eloranta

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Patricia Fitzgerald-Bocarsly

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Rivka C Stone

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Sukhwinder Singh

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P2860

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes

Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes

Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function

Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling

The 1982 revised criteria for the classification of systemic lupus erythematosus

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scholarly article

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10.1002/ART.33395

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3

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64

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2012-03-01T00:00:00Z

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51690390

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21968701

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