The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid.
about
TRIM E3 ligases interfere with early and late stages of the retroviral life cycleHIV type 1 Gag as a target for antiviral therapyIndependent evolution of an antiviral TRIMCyp in rhesus macaquesOptimal cytoplasmic transport in viral infectionsTRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus MonkeysRhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfacesFates of retroviral core components during unrestricted and TRIM5-restricted infectionA rare null allele potentially encoding a dominant-negative TRIM5alpha protein in Baka pygmiesSolid-state NMR studies of HIV-1 capsid protein assemblies.Hexagonal assembly of a restricting TRIM5alpha proteinThe structural biology of HIV assembly.Superresolution imaging of HIV in infected cells with FlAsH-PALMTRIM5 alpha drives SIVsmm evolution in rhesus macaques.Proteasomal degradation of TRIM5alpha during retrovirus restrictionFunctional evidence for the involvement of microtubules and dynein motor complexes in TRIM5α-mediated restriction of retroviruses.Novel approaches to inhibiting HIV-1 replication.Characterization of a core fragment of the rhesus monkey TRIM5α protein.Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core.SUMO-interacting motifs of human TRIM5α are important for antiviral activityThe specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain.TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitro.Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier.Revisiting HIV-1 uncoating.A novel aminoacid determinant of HIV-1 restriction in the TRIM5α variable 1 region isolated in a random mutagenic screenElevated rate of fixation of endogenous retroviral elements in Haplorhini TRIM5 and TRIM22 genomic sequences: impact on transcriptional regulation.Induction of pluripotent stem cells from a cynomolgus monkey using a polycistronic simian immunodeficiency virus-based vector, differentiation toward functional cardiomyocytes, and generation of stably expressing reporter lines.Assisted evolution enables HIV-1 to overcome a high TRIM5α-imposed genetic barrier to rhesus macaque tropism.The fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoatingTrafficking of some old world primate TRIM5α proteins through the nucleus.Modulation of TRIM5alpha activity in human cells by alternatively spliced TRIM5 isoforms.Role of TRIM5α RING domain E3 ubiquitin ligase activity in capsid disassembly, reverse transcription blockade, and restriction of simian immunodeficiency virus.Potent restriction of HIV-1 and SIVmac239 replication by African green monkey TRIM5α.Contribution of E3-ubiquitin ligase activity to HIV-1 restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha.African green monkey TRIM5α restriction in simian immunodeficiency virus-specific rhesus macaque effector CD4 T cells enhances their survival and antiviral function.RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoatingTRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus.SJP-L-5, a novel small-molecule compound, inhibits HIV-1 infection by blocking viral DNA nuclear entry.Advances in cell and gene-based therapies for cystic fibrosis lung diseaseFunctional interplay between the B-box 2 and the B30.2(SPRY) domains of TRIM5alpha
P2860
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P2860
The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The human TRIM5alpha restricti ...... murine leukemia virus capsid.
@ast
The human TRIM5alpha restricti ...... murine leukemia virus capsid.
@en
type
label
The human TRIM5alpha restricti ...... murine leukemia virus capsid.
@ast
The human TRIM5alpha restricti ...... murine leukemia virus capsid.
@en
prefLabel
The human TRIM5alpha restricti ...... murine leukemia virus capsid.
@ast
The human TRIM5alpha restricti ...... murine leukemia virus capsid.
@en
P2093
P2860
P356
P1433
P1476
The human TRIM5alpha restricti ...... murine leukemia virus capsid.
@en
P2093
Byeongwoon Song
Hassan Javanbakht
Matthew Stremlau
Michel J Perron
P2860
P304
P356
10.1128/JVI.02318-06
P407
P577
2006-11-29T00:00:00Z