The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.
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A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication.The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene.Alternative splicing of the human cytomegalovirus major immediate-early genes affects infectious-virus replication and control of cellular cyclin-dependent kinase.The human cytomegalovirus gene products essential for late viral gene expression assemble into prereplication complexes before viral DNA replication.The effect of murine cytomegalovirus IE-3 specific shRNA is dependent on intragenic target site due to multiple transcription initiation sitesMutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32.Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected CellsDifferentiation-Coupled Induction of Human Cytomegalovirus Replication by Union of the Major Enhancer Retinoic Acid, Cyclic AMP, and NF-κB Response Elements.A cis element between the TATA Box and the transcription start site of the major immediate-early promoter of human cytomegalovirus determines efficiency of viral replication.Noncanonical TATA sequence in the UL44 late promoter of human cytomegalovirus is required for the accumulation of late viral transcripts.A fusion protein of HCMV IE1 exon4 and IE2 exon5 stimulates potent cellular immunity in an MVA vaccine vector.Identification and function of human cytomegalovirus microRNAs.Multiple Transcripts Encode Full-Length Human Cytomegalovirus IE1 and IE2 Proteins during Lytic Infection.Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteinsHuman cytomegalovirus encoded microRNAs: hitting targets.High-throughput screening of a GlaxoSmithKline protein kinase inhibitor set identifies an inhibitor of human cytomegalovirus replication that prevents CREB and histone H3 post-translational modification.Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication.Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products.Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses.Internal deletions of IE2 86 and loss of the late IE2 60 and IE2 40 proteins encoded by human cytomegalovirus affect the levels of UL84 protein but not the amount of UL84 mRNA or the loading and distribution of the mRNA on polysomesMurine gammaherpesvirus 68 open reading frame 24 is required for late gene expression after DNA replication.Transcription of true late (γ2) cytomegalovirus genes requires UL92 function that is conserved among beta- and gammaherpesviruses.Human cytomegalovirus early protein pUL21a promotes efficient viral DNA synthesis and the late accumulation of immediate-early transcripts.Cytomegalovirus UL91 is essential for transcription of viral true late (γ2) genes.Human cytomegalovirus and Herpes Simplex type I virus can engage RNA polymerase I for transcription of immediate early genes.Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data
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The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.
description
2007 nî lūn-bûn
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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name
The IE2 60-kilodalton and 40-k ...... roduction of infectious virus.
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The IE2 60-kilodalton and 40-k ...... roduction of infectious virus.
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type
label
The IE2 60-kilodalton and 40-k ...... roduction of infectious virus.
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The IE2 60-kilodalton and 40-k ...... roduction of infectious virus.
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The IE2 60-kilodalton and 40-k ...... roduction of infectious virus.
@ast
The IE2 60-kilodalton and 40-k ...... roduction of infectious virus.
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P2093
P2860
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The IE2 60-kilodalton and 40-k ...... production of infectious virus
@en
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Christia J Del Rosario
Elizabeth A White
Rebecca L Sanders
P2860
P304
P356
10.1128/JVI.02454-06
P407
P577
2007-01-03T00:00:00Z