Absence of IE1 p72 protein function during low-multiplicity infection by human cytomegalovirus results in a broad block to viral delayed-early gene expression.
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Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcriptionAbility of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cellsSynergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gammaIntrinsic host restriction factors of human cytomegalovirus replication and mechanisms of viral escapeProlonged activation of NF-kappaB by human cytomegalovirus promotes efficient viral replication and late gene expressionHuman cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface.Elimination of ie1 significantly attenuates murine cytomegalovirus virulence but does not alter replicative capacity in cell cultureRepression of human cytomegalovirus major immediate early gene expression by the cellular transcription factor CCAAT displacement protein.Exon 3 of the human cytomegalovirus major immediate-early region is required for efficient viral gene expression and for cellular cyclin modulation.Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γTwo Sp1/Sp3 binding sites in the major immediate-early proximal enhancer of human cytomegalovirus have a significant role in viral replication.Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.Alternative splicing of the human cytomegalovirus major immediate-early genes affects infectious-virus replication and control of cellular cyclin-dependent kinase.Anticytomegalovirus activity of pristimerin, a triterpenoid quinone methide isolated from Maytenus heterophylla (Eckl. & Zeyh.).The human cytomegalovirus major immediate-early enhancer determines the efficiency of immediate-early gene transcription and viral replication in permissive cells at low multiplicity of infection.A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signalingMouse cytomegalovirus crosses the species barrier with help from a few human cytomegalovirus proteinsSUMOylation of the human cytomegalovirus 72-kilodalton IE1 protein facilitates expression of the 86-kilodalton IE2 protein and promotes viral replicationHuman cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.Viral product trafficking to mitochondria, mechanisms and roles in pathogenesis.The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like ResponseImmediate-Early (IE) gene regulation of cytomegalovirus: IE1- and pp71-mediated viral strategies against cellular defensesInteractions between DNA viruses, ND10 and the DNA damage response.A cis element between the TATA Box and the transcription start site of the major immediate-early promoter of human cytomegalovirus determines efficiency of viral replication.Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency.Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes.Transactivation of cellular genes involved in nucleotide metabolism by the regulatory IE1 protein of murine cytomegalovirus is not critical for viral replicative fitness in quiescent cells and host tissuesBinding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO.Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoterPhysical requirements and functional consequences of complex formation between the cytomegalovirus IE1 protein and human STAT2.Role of the proximal enhancer of the major immediate-early promoter in human cytomegalovirus replication.Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation.The human cytomegalovirus major immediate-early proteins as antagonists of intrinsic and innate antiviral host responses.Histone modifications in herpesvirus infections.Biology and pathogenesis of cytomegalovirus in periodontal disease.Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome.Analysis of the functional interchange between the IE1 and pp71 proteins of human cytomegalovirus and ICP0 of herpes simplex virus 1.Human cytomegalovirus IE72 protein interacts with the transcriptional repressor hDaxx to regulate LUNA gene expression during lytic infection.Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses.
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P2860
Absence of IE1 p72 protein function during low-multiplicity infection by human cytomegalovirus results in a broad block to viral delayed-early gene expression.
description
2002 nî lūn-bûn
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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2002 թվականի մայիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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name
Absence of IE1 p72 protein fun ...... delayed-early gene expression.
@ast
Absence of IE1 p72 protein fun ...... delayed-early gene expression.
@en
Absence of IE1 p72 protein fun ...... delayed-early gene expression.
@nl
type
label
Absence of IE1 p72 protein fun ...... delayed-early gene expression.
@ast
Absence of IE1 p72 protein fun ...... delayed-early gene expression.
@en
Absence of IE1 p72 protein fun ...... delayed-early gene expression.
@nl
prefLabel
Absence of IE1 p72 protein fun ...... delayed-early gene expression.
@ast
Absence of IE1 p72 protein fun ...... delayed-early gene expression.
@en
Absence of IE1 p72 protein fun ...... delayed-early gene expression.
@nl
P2860
P1433
P1476
Absence of IE1 p72 protein fun ...... delayed-early gene expression.
@en
P2093
Jonathan M Gawn
Richard F Greaves
P2860
P304
P356
10.1128/JVI.76.9.4441-4455.2002
P407
P577
2002-05-01T00:00:00Z