Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant.
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Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infectionsRepression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcriptionHuman cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expressionViral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruptionProteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression.Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expressionAbility of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cellsSynergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gammaAnalysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during infectionIntrinsic host restriction factors of human cytomegalovirus replication and mechanisms of viral escapeProlonged activation of NF-kappaB by human cytomegalovirus promotes efficient viral replication and late gene expressionNonnucleoside pyrrolopyrimidines with a unique mechanism of action against human cytomegalovirusInhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activityHuman cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface.A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication.Activation of transcription of the human cytomegalovirus early UL4 promoter by the Ets transcription factor binding element.Human cytomegalovirus latency-associated protein pORF94 is dispensable for productive and latent infection.Focal transcriptional activity of murine cytomegalovirus during latency in the lungs.Perivascular stromal cells as a potential reservoir of human cytomegalovirus.Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PMLEnhancer requirement for murine cytomegalovirus growth and genetic complementation by the human cytomegalovirus enhancer.A cis repression sequence adjacent to the transcription start site of the human cytomegalovirus US3 gene is required to down regulate gene expression at early and late times after infectionElimination of ie1 significantly attenuates murine cytomegalovirus virulence but does not alter replicative capacity in cell cultureThe human cytomegalovirus major immediate-early distal enhancer region is required for efficient viral replication and immediate-early gene expression.The human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into the S phase of permissive cells.A strong negative transcriptional regulatory region between the human cytomegalovirus UL127 gene and the major immediate-early enhancer.The human cytomegalovirus IE2 and UL112-113 proteins accumulate in viral DNA replication compartments that initiate from the periphery of promyelocytic leukemia protein-associated nuclear bodies (PODs or ND10)Repression of human cytomegalovirus major immediate early gene expression by the cellular transcription factor CCAAT displacement protein.Reactivation of the human cytomegalovirus major immediate-early regulatory region and viral replication in embryonal NTera2 cells: role of trichostatin A, retinoic acid, and deletion of the 21-base-pair repeats and modulator.Exon 3 of the human cytomegalovirus major immediate-early region is required for efficient viral gene expression and for cellular cyclin modulation.Evaluation of interactions of human cytomegalovirus immediate-early IE2 regulatory protein with small ubiquitin-like modifiers and their conjugation enzyme Ubc9Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γTwo Sp1/Sp3 binding sites in the major immediate-early proximal enhancer of human cytomegalovirus have a significant role in viral replication.Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest responseInhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activityHuman cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.Requirement of multiple cis-acting elements in the human cytomegalovirus major immediate-early distal enhancer for viral gene expression and replication.SUMO-1 modification of human cytomegalovirus IE1/IE72Regulation of Sp100A subnuclear localization and transcriptional function by EBNA-LP and interferon.
P2860
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P2860
Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Defective growth correlates wi ...... an cytomegalovirus ie1 mutant.
@ast
Defective growth correlates wi ...... an cytomegalovirus ie1 mutant.
@en
type
label
Defective growth correlates wi ...... an cytomegalovirus ie1 mutant.
@ast
Defective growth correlates wi ...... an cytomegalovirus ie1 mutant.
@en
prefLabel
Defective growth correlates wi ...... an cytomegalovirus ie1 mutant.
@ast
Defective growth correlates wi ...... an cytomegalovirus ie1 mutant.
@en
P2860
P1433
P1476
Defective growth correlates wi ...... an cytomegalovirus ie1 mutant.
@en
P2093
E S Mocarski
R F Greaves
P2860
P304
P577
1998-01-01T00:00:00Z