Modulation of signalling by Sprouty: a developing story.
about
The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective mannerDirect association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactionsA novel role of Sprouty 2 in regulating cellular apoptosisRelief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomasSprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulationTargeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or functionTbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortexExpression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomasFunctional analysis of human hematopoietic stem cell gene expression using zebrafish.A high throughput messenger RNA differential display screen identifies discrete domains of gene expression and novel patterning processes along the developing neural tube.Mnk kinase pathway: Cellular functions and biological outcomesDA-Raf-Mediated Suppression of the Ras--ERK Pathway Is Essential for TGF-β1-Induced Epithelial-Mesenchymal Transition in Alveolar Epithelial Type 2 CellsRaf-interactome in tuning the complexity and diversity of Raf function.Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to HerceptinA functional interaction between sprouty proteins and caveolin-1The Cbl interactome and its functionsThe intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathwayRaf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activationGerm Line Versus Soma in the Transition from Egg to EmbryoPhenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a modelWnt signaling in the murine diastemaRegulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signalingRegulation of sprouty stability by Mnk1-dependent phosphorylation.Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in miceNuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells.Cooperative and independent functions of FGF and Wnt signaling during early inner ear development.Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal.Decreased expression of Sprouty2 in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder: a correlation with BDNF expression.The VASP-Spred-Sprouty domain puzzle.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors.SHP-2 is required for the maintenance of cardiac progenitors.Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene.Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling.Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degenerationHormonal and local control of mammary branching morphogenesisClinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancerDirecting traffic in neural cells: determinants of receptor tyrosine kinase localization and cellular responses.FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size.
P2860
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P2860
Modulation of signalling by Sprouty: a developing story.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Modulation of signalling by Sprouty: a developing story.
@ast
Modulation of signalling by Sprouty: a developing story.
@en
type
label
Modulation of signalling by Sprouty: a developing story.
@ast
Modulation of signalling by Sprouty: a developing story.
@en
prefLabel
Modulation of signalling by Sprouty: a developing story.
@ast
Modulation of signalling by Sprouty: a developing story.
@en
P356
P1476
Modulation of signalling by Sprouty: a developing story.
@en
P2093
Hong Joo Kim
P2888
P304
P356
10.1038/NRM1400
P577
2004-06-01T00:00:00Z