Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1
about
Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore openinghERG-related drug toxicity and models for predicting hERG liability and QT prolongation.The S631A mutation causes a mechanistic switch in the block of hERG channels by CnErg1.Interactions at human ether-à-go-go-related gene channels.Temperature Effects on Kinetics of KV11.1 Drug Block Have Important Consequences for In Silico Proarrhythmic Risk Prediction.A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel.PKC inhibition results in a Kv 1.5 + Kv β1.3 pharmacology closer to Kv 1.5 channels.In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details.Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis.Modulation of Ether-à-Go-Go Related Gene (ERG) Current Governs Intrinsic Persistent Activity in Rodent Neocortical Pyramidal Cells.
P2860
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P2860
Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1
description
2007 nî lūn-bûn
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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2007年论文
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2007年论文
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name
Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1
@ast
Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1
@en
type
label
Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1
@ast
Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1
@en
prefLabel
Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1
@ast
Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1
@en
P2860
P1433
P1476
Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1
@en
P2093
Adam P Hill
T J Campbell
P2860
P304
P356
10.1529/BIOPHYSJ.106.101956
P407
P577
2007-03-16T00:00:00Z