Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein.
about
Human Papillomavirus: Current and Future RNAi Therapeutic Strategies for Cervical CancerNucleic acid aptamers: research tools in disease diagnostics and therapeuticsFunctional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical SitesUtility of microRNAs and siRNAs in cervical carcinogenesisInduction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP geneActivation and activities of the p53 tumour suppressor proteinThe E6AP binding pocket of the HPV16 E6 oncoprotein provides a docking site for a small inhibitory peptide unrelated to E6AP, indicating druggability of E6Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics.Peptide aptamers targeting the hepatitis B virus core protein: a new class of molecules with antiviral activity.Inhibition of human cytomegalovirus replication via peptide aptamers directed against the nonconventional nuclear localization signal of the essential viral replication factor pUL84.Genetic selection for modulators of a retinoic-acid-responsive reporter in human cellsSequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.Identification using phage display of peptides promoting targeting and internalization into HPV-transformed cell lines.Targeted modification and transportation of cellular proteins.Peptide aptamers: recent developments for cancer therapy.Peptide aptamers that bind to a geminivirus replication protein interfere with viral replication in plant cellsModulation of Nr-13 antideath activity by peptide aptamers.Peptide aptamers as new tools to modulate clathrin-mediated internalisation--inhibition of MT1-MMP internalisation.Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53Identification and characterization of small molecule human papillomavirus E6 inhibitorssiRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells.Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cellsThe human papillomavirus E6 protein and its contribution to malignant progression.P53: an ubiquitous target of anticancer drugs.Regulation of apoptosis by the papillomavirus E6 oncogene.Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.Regulation of senescence in cancer and aging.Pitx2a binds to human papillomavirus type 18 E6 protein and inhibits E6-mediated P53 degradation in HeLa cells.Peptide-mediated broad-spectrum plant resistance to tospoviruses.Leukemia inhibitory factor downregulates human papillomavirus-16 oncogene expression and inhibits the proliferation of cervical carcinoma cells.Emerging drugs to treat squamous cell carcinomas of the head and neck.Oncogenic human papillomaviruses activate the tumor-associated lens epithelial-derived growth factor (LEDGF) gene.Peptides with anticancer use or potential.Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells.Targeting the human papillomavirus E6 and E7 oncogenes through expression of the bovine papillomavirus type 1 E2 protein stimulates cellular motility.The integration of a Stat3 specific peptide aptamer into the thioredoxin scaffold protein strongly enhances its inhibitory potency.Molecular Mechanism and Potential Targets for Blocking HPV-Induced Lesion DevelopmentIntracellular Analysis of the Interaction between the Human Papillomavirus Type 16 E6 Oncoprotein and Inhibitory Peptides.Advances in the development of therapeutic nucleic acids against cervical cancer.
P2860
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P2860
Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Induction of apoptosis in huma ...... ting the viral E6 oncoprotein.
@ast
Induction of apoptosis in huma ...... ting the viral E6 oncoprotein.
@en
type
label
Induction of apoptosis in huma ...... ting the viral E6 oncoprotein.
@ast
Induction of apoptosis in huma ...... ting the viral E6 oncoprotein.
@en
prefLabel
Induction of apoptosis in huma ...... ting the viral E6 oncoprotein.
@ast
Induction of apoptosis in huma ...... ting the viral E6 oncoprotein.
@en
P2093
P2860
P356
P1476
Induction of apoptosis in huma ...... ting the viral E6 oncoprotein.
@en
P2093
P2860
P304
P356
10.1073/PNAS.110538897
P407
P577
2000-06-01T00:00:00Z