FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.
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FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacologyRoles of bioactive sphingolipids in cancer biology and therapeuticsThe immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptorsPriming of CD8(+) T Cell Responses to Liver Stage Malaria Parasite AntigensExperimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrierFTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosisFTY720 protects cardiac microvessels of diabetes: a critical role of S1P1/3 in diabetic heart diseaseSphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumorInduction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis.Identification of the hydrophobic ligand binding pocket of the S1P1 receptorNovel GPCR screening approach: indirect identification of S1P receptor agonists in antagonist screening using a calcium assay.A comprehensive review of immunosuppression used for liver transplantation.Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis.A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigrationSphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potentialMechanism of action of oral fingolimod (FTY720) in multiple sclerosis.Role of natural product diversity in chemical biology.Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis.Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics.Pharmacological pre- and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusionAdvances in the management of peritoneal mesotheliomaLymphocyte modulation with FTY720 improves hemorrhagic shock survival in swineQuantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry.Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungs"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.Fingolimod for relapsing multiple sclerosis: an update.Compared benefit of approved and experimental immunosuppressive therapeutic approaches in multiple sclerosis.FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3.Predictability of peripheral lymphocyte reduction of novel S1P1 agonists by in vitro GPCR signaling profile.Cancer treatment strategies targeting sphingolipid metabolism.Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis.Oral disease-modifying therapies for multiple sclerosis.Fingolimod (FTY720): First approved oral therapy for multiple sclerosisPlatelets: versatile effector cells in hemostasis, inflammation, and the immune continuumPharmacological relevance and potential of sphingosine 1-phosphate in the vascular system.Sphingosine-1-phosphate receptor 2
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P2860
FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
FTY720: sphingosine 1-phosphat ...... endothelial barrier function.
@ast
FTY720: sphingosine 1-phosphat ...... endothelial barrier function.
@en
type
label
FTY720: sphingosine 1-phosphat ...... endothelial barrier function.
@ast
FTY720: sphingosine 1-phosphat ...... endothelial barrier function.
@en
prefLabel
FTY720: sphingosine 1-phosphat ...... endothelial barrier function.
@ast
FTY720: sphingosine 1-phosphat ...... endothelial barrier function.
@en
P1476
FTY720: sphingosine 1-phosphat ...... d endothelial barrier function
@en
P2093
Jason G Cyster
Volker Brinkmann
P304
P356
10.1111/J.1600-6143.2004.00476.X
P407
P50
P577
2004-07-01T00:00:00Z