The role of the non-homologous end-joining pathway in lymphocyte development.
about
SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair.Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switchingATM damage response and XLF repair factor are functionally redundant in joining DNA breaksDNA double-strand breaks activate a multi-functional genetic program in developing lymphocytesAlternative induction of meiotic recombination from single-base lesions of DNA deaminasesCrystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJThe DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis.DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs.The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivoIgH class switching and translocations use a robust non-classical end-joining pathwayThe response to and repair of RAG-mediated DNA double-strand breaksDefective nonhomologous end joining blocks B-cell development in FLT3/ITD miceFunctional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombinationDNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouseMsl2 is a novel component of the vertebrate DNA damage responseElucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingIn vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.Chromatin structure regulates gene conversion.BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice.Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.Generation and repair of AID-initiated DNA lesions in B lymphocytes.ARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cellsAlternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70Is homologous recombination really an error-free process?Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells.Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and developmentExpression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination.ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.Mechanisms promoting translocations in editing and switching peripheral B cells.KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes.The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival.RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes.Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycleAtaxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complexMechanism and regulation of class switch recombinationKu80 removal from DNA through double strand break-induced ubiquitylation.
P2860
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P2860
The role of the non-homologous end-joining pathway in lymphocyte development.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The role of the non-homologous end-joining pathway in lymphocyte development.
@ast
The role of the non-homologous end-joining pathway in lymphocyte development.
@en
type
label
The role of the non-homologous end-joining pathway in lymphocyte development.
@ast
The role of the non-homologous end-joining pathway in lymphocyte development.
@en
prefLabel
The role of the non-homologous end-joining pathway in lymphocyte development.
@ast
The role of the non-homologous end-joining pathway in lymphocyte development.
@en
P2093
P2860
P1476
The role of the non-homologous end-joining pathway in lymphocyte development.
@en
P2093
Frederick W Alt
Jayanta Chaudhuri
Sean Rooney
P2860
P304
P356
10.1111/J.0105-2896.2004.00165.X
P577
2004-08-01T00:00:00Z