Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70 - Wikidata - awgldk - TriplyDB

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

http://www.wikidata.org/entity/Q33733981

about

Alternative end-joining mechanisms: a historical perspective DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)Alternative Okazaki Fragment Ligation Pathway by DNA Ligase III DNA double-strand break repair pathway choice and cancer Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.Snaps and mends: DNA breaks and chromosomal translocations Homology and enzymatic requirements of microhomology-dependent alternative end joining DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates WRN regulates pathway choice between classical and alternative non-homologous end joining Genomic stability in response to high versus low linear energy transfer radiation in Arabidopsis thaliana.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination.Origin of chromosomal translocations in lymphoid cancer.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions.Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan.AID-initiated DNA lesions are differentially processed in distinct B cell populations.Comparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.ATM release at resected double-strand breaks provides heterochromatin reconstitution to facilitate homologous recombination.Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease.Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes.Parp3 negatively regulates immunoglobulin class switch recombination.An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells.Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair.X-ray repair cross-complementing protein 1 (XRCC1) deficiency enhances class switch recombination and is permissive for alternative end joining.Rapid analysis of chromosome aberrations in mouse B lymphocytes by PNA-FISH.Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining DNA ligase I is not essential for mammalian cell viability.Unexpected effects of different genetic backgrounds on identification of genomic rearrangements via whole-genome next generation sequencing.53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks.

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Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

http://www.wikidata.org/entity/Q33733981

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Alternative end-joining cataly ...... d absence of ligase 4 and Ku70

@ast

Alternative end-joining cataly ...... d absence of ligase 4 and Ku70

@en

type

label

Alternative end-joining cataly ...... d absence of ligase 4 and Ku70

@ast

Alternative end-joining cataly ...... d absence of ligase 4 and Ku70

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prefLabel

Alternative end-joining cataly ...... d absence of ligase 4 and Ku70

@ast

Alternative end-joining cataly ...... d absence of ligase 4 and Ku70

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PNAS.0915067107

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Alternative end-joining cataly ...... d absence of ligase 4 and Ku70

@en

P2093

Alex Fazeli

http://www.w3.org/2001/XMLSchema#string

Andre Nussenzweig

http://www.w3.org/2001/XMLSchema#string

Catherine T Yan

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Cristian Boboila

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Duane R Wesemann

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Frederick W Alt

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Jing H Wang

http://www.w3.org/2001/XMLSchema#string

Lauren Feldman

http://www.w3.org/2001/XMLSchema#string

Mila Jankovic

http://www.w3.org/2001/XMLSchema#string

Tingting Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Internal IgH class switch region deletions are position-independent and enhanced by AID expression

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes

Biochemical evidence for Ku-independent backup pathways of NHEJ

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

IgH class switching and translocations use a robust non-classical end-joining pathway

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

P304

3034-3039

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scholarly article

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10.1073/PNAS.0915067107

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7

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107

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Michel C. Nussenzweig

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2010-01-25T00:00:00Z

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41408655

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20133803

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2840344

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