Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. - Wikidata - awgldk - TriplyDB

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

http://www.wikidata.org/entity/Q35836097

about

Fundamentals of cancer metabolism MYC, Metabolism, and Cancer Amino acid management in cancer ROS homeostasis and metabolism: a dangerous liason in cancer cells Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells.From Krebs to clinic: glutamine metabolism to cancer therapy.Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch.Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC Expression of glutamine metabolism-related proteins in thyroid cancer.PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence.Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma.Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα.Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction.Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells.In vivo Reprogramming of Cancer Metabolism by MYC.Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?How does metabolism affect cell death in cancer?Glutaminolysis as a target for cancer therapy.Drug-induced amino acid deprivation as strategy for cancer therapy.The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.Mitochondria and Cancer.Computational Model Predicts the Effects of Targeting Cellular Metabolism in Pancreatic Cancer.Targeting glutamine metabolism in myeloproliferative neoplasms.MYC, Metabolic Synthetic Lethality, and Cancer.Targeting amino acid metabolism for cancer therapy.T-cell Metabolism as a Target to Control Autoreactive T Cells in β-Cell Autoimmunity.Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors.Glutamine Metabolism in Cancer: Understanding the Heterogeneity.Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine.

P2860

Q26744062-2EC50A7F-812D-48C8-B292-3A251A62C4AE Q26783555-E13989BA-7D64-4DD2-94C8-6DF3A16EA5CA Q26798087-CE09BF24-295B-479D-9DC1-4426A8C02E9E Q28075971-C919031E-B3F1-44AE-B58E-F012EA88B636 Q30391992-DCC64FF2-C67F-4361-8215-48560B9F99B6 Q33607463-A1B38751-A92D-4658-9EF0-171F3AAA5603 Q33617469-19D2F1E5-07CA-42F1-B456-889DDB44B8DD Q33834498-B048D1B7-4D9A-4FE0-B756-4596234AC3BC Q33882228-4B13AF14-392B-47BA-BC86-443A6D25BD2F Q36189879-D3798431-A360-4286-A391-2A7D3AAA7CC0 Q36476849-EB58D8C6-D467-467B-B5D0-DA011F3C003F Q36568490-795305C9-EE28-449D-80E9-376C51AD10AA Q36760018-28080BA4-C7E5-4B4E-B792-A317E7A815E4 Q36946666-434BCC4B-492A-4D2D-97E6-70B82EE7B503 Q37247525-12F07A6F-7489-44CB-A961-645802A63FD6 Q37258774-416B025F-6B83-4690-B3EC-D10C09835E2A Q37603505-DB4C7789-420B-4B9E-B3E4-42F6594E225B Q37619803-603F6844-21D4-407C-B7B4-0B2665A05693 Q37619836-0F445267-7B34-4D92-85CF-E8E103456C28 Q37697049-04664066-741C-4A72-8DF9-39DB7E12938D Q37733806-F35059DC-37C7-4030-ABA4-DF0A48FEE18E Q37740336-C5BFB4AF-BF99-4631-84B8-A618545E0AE5 Q37745850-296B4599-6A32-488A-B2BC-A43BCF98EE6A Q37746816-D2487768-5737-4391-A662-F4B337DA971A Q38592248-D979BB0F-236C-4BBF-8C3C-EC1E689E45F9 Q38612793-B358D2F3-D977-4469-B796-B1BDC6FB4987 Q38615890-CF70212F-54DB-4AA8-8902-3F9B51EEDBFF Q38642387-154215E1-FE78-40FE-8E82-EB633B835ACE Q38657061-BA05FDE4-C34F-433F-8F45-FA4AF9FCE524 Q38707758-A5AECFBE-5680-45C7-A103-F6F820B01B33 Q38715579-C9408415-C52E-4EAC-8617-224A3BD32E45 Q38760551-19A9BD48-1288-4FBB-967A-42E63637E4A5 Q38817911-0F7307CE-F942-4E97-88CA-FD75244AD9C9 Q38847693-7FDF4A9B-E680-4190-B424-1815240BC295 Q38936255-43CB2BBF-3479-4C35-9F87-B22677EB5B67 Q39042260-637C2BAC-57C0-4A8E-819E-5C24A52D3BDD Q39183146-121F3C01-58A6-4BDE-B018-ED4EFA9437BE Q39205930-26B3AE79-EE8D-465B-B0C9-49078BCFE1CC Q39230796-5E08F1CB-3245-4412-8933-EA9C950390C3 Q39249420-E5602F3A-6027-4BDC-9C7D-104B93A8E6CA

P2860

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

http://www.wikidata.org/entity/Q35836097

description

2015 nî lūn-bûn

@nan

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

2015年论文

@zh

2015年论文

@zh-cn

name

Targeted inhibition of tumor-s ...... cell-autonomous tumorigenesis.

@ast

Targeted inhibition of tumor-s ...... cell-autonomous tumorigenesis.

@en

type

label

Targeted inhibition of tumor-s ...... cell-autonomous tumorigenesis.

@ast

Targeted inhibition of tumor-s ...... cell-autonomous tumorigenesis.

@en

prefLabel

Targeted inhibition of tumor-s ...... cell-autonomous tumorigenesis.

@ast

Targeted inhibition of tumor-s ...... cell-autonomous tumorigenesis.

@en

P1433

Q35836097-D4E7BA1F-5047-4EAB-8A96-274C2E0C3A88

P1476

Q35836097-F790D2C6-29BB-4554-8657-45F8EFE57384

P2093

Q35836097-03653860-9145-4F2E-9516-FA1E3A6F004B

Q35836097-0369B6C2-83CE-4568-BE8E-5EE1801091D2

Q35836097-13142253-1789-4609-8151-F41FF37DDA77

Q35836097-26947DE8-CB1E-4D2F-9BF6-2E9EE845D181

Q35836097-3E518A1F-79AF-4AFA-9A81-2F1A2E15CCFE

Q35836097-5699D396-5C8F-47C1-9D6C-3AF59140C8D5

Q35836097-6974D445-F43D-4F08-B353-FF3555D2AD97

Q35836097-8174D086-E97E-4802-9BFE-4AA2EB3E6E97

Q35836097-91826E45-2FD5-4410-8966-9C5D28A0BA69

Q35836097-A4C2B6DD-BC08-4EC3-B74A-626DE0A40036

P2860

Q35836097-04165EDE-A581-454E-A2EF-6361F5AEACB1

Q35836097-0B638E35-C0B2-41EA-84E4-1611B241BAAB

Q35836097-0C297ED5-A0B2-4240-8F37-7AE33AD0AE15

Q35836097-20A4423B-4F21-4D93-B147-5DFCE11B19E7

Q35836097-217064DE-6FEC-4578-81D4-944CF0208055

Q35836097-22C5B79F-D79E-4338-9EAF-08BE8DE1FBB7

Q35836097-2771F087-05D2-49E2-859F-6A8678E3758A

Q35836097-2A515939-CD64-4776-9B61-ED6E59F56C5B

Q35836097-2FBDB2D9-BFB9-4D37-913D-E85BF4429C68

Q35836097-34C02CFA-8F22-4B30-B47F-D9D899A28742

P304

Q35836097-669ABA30-EA06-41B9-BDF0-488B44599F56

P31

Q35836097-848D52FF-2625-482B-B3C1-B05424AC0C09

P356

Q35836097-FE70EC8C-1B3B-4B6A-83A6-4F19502CFC6F

P407

Q35836097-CDFB1236-7FD6-420F-977B-07E401AB4A13

P433

Q35836097-88E49A7A-E253-4E17-9B2D-0AA37BA099A0

P478

Q35836097-E1969B9B-42F1-45FF-8B52-F084DB6BC072

P50

Q35836097-12BBC8F9-C3A0-4C0E-837B-8130C3FCA7F0

Q35836097-4759120C-1373-4F9F-A16D-5F2D93F2C6BE

Q35836097-A70AB953-FFDF-4E6D-9E51-4817FC31769A

Q35836097-AF2407DC-8370-4C39-B110-D4140B6F9B1F

P577

Q35836097-CAC17139-BBEC-44E7-827C-C5EA97585E44

P698

Q35836097-8888C404-570E-49E8-8D31-3C690D098B13

P932

Q35836097-99A46A29-D9CB-48CB-950B-AD2569AB0558

P356

P1433

Journal of Clinical Investigation

P1476

Targeted inhibition of tumor-s ...... cell-autonomous tumorigenesis

@en

P2093

Ajit G Thomas

http://www.w3.org/2001/XMLSchema#string

Andrew S McCallion

http://www.w3.org/2001/XMLSchema#string

Annie L Hsieh

http://www.w3.org/2001/XMLSchema#string

Anthony Mancuso

http://www.w3.org/2001/XMLSchema#string

Arvin M Gouw

http://www.w3.org/2001/XMLSchema#string

Barbara S Slusher

http://www.w3.org/2001/XMLSchema#string

Benedict Yan

http://www.w3.org/2001/XMLSchema#string

Caroline G L Lee

http://www.w3.org/2001/XMLSchema#string

Dean W Felsher

http://www.w3.org/2001/XMLSchema#string

Jingli Zhuo

http://www.w3.org/2001/XMLSchema#string

P2860

Targeting aspartate aminotransferase in breast cancer

Full-length human glutaminase in complex with an allosteric inhibitor

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

Developmental context determines latency of MYC-induced tumorigenesis

Glutamine and cancer: cell biology, physiology, and clinical opportunities

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor

Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation

P304

2293-2306

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI75836

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

125

http://www.w3.org/2001/XMLSchema#string

P50

Brian J. Altman

P577

2015-04-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

25915584

http://www.w3.org/2001/XMLSchema#string

P932

4497742

http://www.w3.org/2001/XMLSchema#string